Actively Recruiting

Phase Not Applicable
Age: 30Years - 65Years
All Genders
NCT04937998

PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT

Led by Istituto Ortopedico Rizzoli · Updated on 2025-12-04

166

Participants Needed

1

Research Sites

200 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The aim of the study is to compare the 12-month clinical outcomes of patients with patellofemoral osteoarthritis undergoing infiltrative treatment with fresh PRP and HA

CONDITIONS

Official Title

PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT

Who Can Participate

Age: 30Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 30 and 65
  • Signs and symptoms of isolated patellofemoral osteoarthritis in one or both knees
  • Radiographic evidence of isolated patellofemoral osteoarthritis (Iwano stage 1-3) or chondropathy with K-L grade  2 in other compartments
  • Hemoglobin > 11 g/dl and Platelet count > 150,000 plt/mm3 from recent blood tests
  • No clinically significant electrocardiographic abnormalities from recent ECG
  • Ability and willingness to actively participate in clinical follow-up
  • Signed informed consent
Not Eligible

You will not qualify if you...

  • Unable to give consent
  • Received intra-articular injections within the past 6 months
  • Underwent knee surgery in the past 12 months
  • Presence of malignant neoplasms
  • Rheumatic diseases
  • Diabetes
  • Hematologic diseases (coagulopathies)
  • Currently on anticoagulant or antiaggregant therapy
  • Thyroid metabolic disorders
  • Abuse of alcohol, drugs, or medications
  • Body Mass Index over 35
  • Used NSAIDs in the 3 days before blood draw
  • Cardiovascular conditions contraindicating a 60 mL blood draw
  • Recent blood tests showing hemoglobin < 11 g/dl or platelets < 150,000 plt/mm3
  • Previous treatment for patellar dislocation
  • Iwano score of grade 4

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Istituto Ortopedico Rizzoli

Bologna, Italy

Actively Recruiting

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Research Team

R

Roberta Licciardi, MSc

CONTACT

A

Alessandro Di Martino, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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