Study of Advanced Whole-Body MRI Using Pseudo-scanner Sequences to Detect Bone Lesions in Multiple Myeloma

What this Trial Is About

This research evaluates new MRI techniques called pseudo-CT sequences, designed to improve the detection of bone lesions in people with multiple myeloma bone disease. These sequences aim to combine bone marrow assessment and bone damage detection in a single, non-irradiating imaging exam. Advances include using deep learning to enhance image quality and correct artifacts, which may increase diagnostic accuracy compared to current imaging methods. The study uses whole-body MRI with optimized pseudo-CT sequences like Zero Echo Time ZTE and Lava Flex Low Flip Angle LF, which better visualize mineral bone similar to CT scans but without radiation exposure. Participants receive standard care follow-up with PETCT and whole-body MRI incorporating these new sequences. This approach seeks to compare the diagnostic performance of these imaging protocols during the study. Participants will undergo imaging assessments for about one year, including both traditional PETCT and the new whole-body MRI with pseudo-CT sequences. Researchers will evaluate how well these imaging methods detect bone lesions by comparing sensitivity and predictive accuracy. The study monitors all imaging results to understand the diagnostic value of these new MRI techniques for multiple myeloma bone disease.

"Pseudo-scanner" MRI Sequences for the Detection of Bone Lesions in Multiple Myeloma