Actively Recruiting
PSMA PET for the Staging and Management of Hepatocellular Carcinoma
Led by VA Office of Research and Development · Updated on 2025-07-23
90
Participants Needed
1
Research Sites
210 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
M
Miami VA Healthcare System
Collaborating Sponsor
AI-Summary
What this Trial Is About
This prospective, single-center study evaluates the clinical utility of F18-Piflufolastat (PSMA) PET/CT when added to conventional cross-sectional imaging for patients with suspected or confirmed hepatocellular carcinoma (HCC). The study aims to determine whether PSMA PET/CT improves diagnostic accuracy for indeterminate liver lesions (LI-RADS 3 and 4), enhances staging precision in treatment-naïve patients, and provides more accurate assessment of treatment response in patients undergoing locoregional therapy (LRT). The goal is to assess how PSMA PET/CT may impact clinical decision-making, staging, and management of HCC across multiple stages of disease.
CONDITIONS
Official Title
PSMA PET for the Staging and Management of Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients age >18 years from the VA medical system
- Treatment-nafve patients with HCC with BCLC B or C disease
You will not qualify if you...
- Patients with renal dysfunction or contrast allergy that precludes contrast enhanced cross sectional imaging
- Patients with presence of active primary malignancy other than HCC and non-melanoma skin cancer in the past 3 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Miami VA Healthcare System, Miami, FL
Miami, Florida, United States, 33125
Actively Recruiting
Research Team
B
Binu V John, MD MPH
CONTACT
F
Flavia R Carneiro, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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