Actively Recruiting
PSMA-PET/CT to Assess the Expression of Specific Membrane Antigen (PSMA) in Patients With Progressive Triple-negative Breast Cancer.
Led by Jules Bordet Institute · Updated on 2025-07-18
20
Participants Needed
1
Research Sites
183 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a descriptive, prospective, single centre study. This study will assess PSMA expression via the uptake of radiolabelled PSMA-ligand using PET/CT imaging in mTNBC lesions pre-identified on 18F-FDG PET/CT in order to evaluate the feasibility of molecular radionuclide therapy in refractory mTNBC using the Lutetium-177 radiolabelled PSMA.
CONDITIONS
Official Title
PSMA-PET/CT to Assess the Expression of Specific Membrane Antigen (PSMA) in Patients With Progressive Triple-negative Breast Cancer.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent obtained before any study procedures
- Female patients aged 18 years or older
- Eastern Cooperative Oncology Group Performance Status of 0 to 2
- Confirmed diagnosis of progressive metastatic triple-negative breast cancer
- Measurable disease on 18F-FDG PET/CT within 2 weeks or brain MRI within 4 weeks for brain metastases
- PSMA PET/CT must be performed before starting the next treatment line
You will not qualify if you...
- Pregnant or lactating patients
- Presence of other active cancer diseases
- Treatment with another investigational drug within 30 days
- Metastatic disease limited only to the skin
- Significant medical, neuro-psychiatric, or surgical conditions that may interfere with study completion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institut Jules Bordet
Brussels, Belgium
Actively Recruiting
Research Team
G
Géraldine Gebhart, MD
CONTACT
L
Loubna Taraji, Ms
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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