Actively Recruiting
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Led by Petter Bjornstad · Updated on 2025-03-24
100
Participants Needed
2
Research Sites
322 weeks
Total Duration
On this page
Sponsors
P
Petter Bjornstad
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.
CONDITIONS
Official Title
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- HbA1c 6.0% or higher for untreated high-risk group
- Body mass index (BMI) at or above the 85th percentile for high-risk group
- Normal HbA1c 5.6% or lower for control group
- Negative for type 1 diabetes antibodies
You will not qualify if you...
- History of chronic kidney disease (CKD) or acute kidney injury (AKI)
- Metabolic disorder that prevents safe fasting
- Allergy to iodine or penicillin
- Pregnancy
- Thrombophilia
- Contraindications to MRI
- Use of hormone therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
2
Seattle Children's Hospital
Seattle, Washington, United States, 98102
Actively Recruiting
Research Team
P
Petter Bjornstad, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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