Actively Recruiting
Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy
Led by NYU Langone Health · Updated on 2026-05-01
500
Participants Needed
40
Research Sites
205 weeks
Total Duration
On this page
Sponsors
N
NYU Langone Health
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
PE-TRACT is an open-label, assessor-blinded, randomized trial, aiming to compare catheter-directed therapy (CDT) and anticoagulation (CDT group) with anticoagulation alone (No-CDT) in 500 patients with submassive PE, proximal pulmonary artery thrombus and right ventricular dilation.
CONDITIONS
Official Title
Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Symptomatic pulmonary embolism diagnosed by contrast-enhanced CT angiography involving a main or lobar pulmonary artery branch
- Right ventricular enlargement defined by an RV/Left ventricular ratio greater than 1 on CT angiography
You will not qualify if you...
- Age under 18 years
- Low blood pressure below 90 mmHg for over 15 minutes or significant drop from baseline, or need for blood pressure support medications within 1 hour before assessment
- Symptoms lasting more than 14 days for the current pulmonary embolism
- Irreversible high INR greater than 3
- Irreversible low platelet count below 50,000/microliter
- Kidney dysfunction with creatinine over 2.0 mg/dl
- Low hemoglobin below 7.0 g/dl
- Pregnancy confirmed by urine or blood test within 7 days prior to randomization
- Allergy or sensitivity to recombinant tissue plasminogen activator or iodinated contrast, except mild to moderate contrast allergies treatable with steroids
- Life expectancy less than 1 year
- Chronic inability to walk independently before the current pulmonary embolism episode
- Allergy to heparin or history of heparin-induced thrombocytopenia
- Unable or unwilling to provide informed consent
- Major contraindications or unsuitability for all catheter-directed therapy methods available at the study center
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 40 locations
1
The University of Alabama At Birmingham
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
Stanford Medicine
Palo Alto, California, United States, 94304
Actively Recruiting
3
UC Davis Health
Sacramento, California, United States, 95817
Actively Recruiting
4
Scripps Memorial Hospital, La Jolla
San Diego, California, United States, 92121
Actively Recruiting
5
The Lundquist Institute
Torrance, California, United States, 90502
Actively Recruiting
6
Christiana Care
Newark, Delaware, United States, 19718
Actively Recruiting
7
MedStar Health Research Institute
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
8
Baptist Health Miami Cardiac & Vascular Institute
Miami, Florida, United States, 33176
Actively Recruiting
9
University of South Florida/ Tampa General Hospital
Tampa, Florida, United States, 33606
Actively Recruiting
10
Emory University School of Medicine
Atlanta, Georgia, United States, 30308
Actively Recruiting
11
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
12
Advocate Good Samaritan Hospital
Downers Grove, Illinois, United States, 60515
Actively Recruiting
13
Loyola University Chicago
Maywood, Illinois, United States, 60153
Actively Recruiting
14
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62781
Actively Recruiting
15
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
16
MaineHealth
Portland, Maine, United States, 04102
Actively Recruiting
17
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
18
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
19
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
20
Trinity Health - Ann Arbor Hospital
Ypsilanti, Michigan, United States, 48197
Actively Recruiting
21
Washington University in St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
22
Rutgers New Jersey Medical School
Newark, New Jersey, United States, 07103
Actively Recruiting
23
University of New Mexico Health Sciences Center
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
24
NYU Langone Health - Tisch Hospital
New York, New York, United States, 10016
Actively Recruiting
25
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
26
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
27
Promedica
Toledo, Ohio, United States, 43606
Actively Recruiting
28
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
29
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
30
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
31
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
32
Main Line Healh
Wynnewood, Pennsylvania, United States, 19096
Actively Recruiting
33
Lifespan
Providence, Rhode Island, United States, 02903
Actively Recruiting
34
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
35
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
36
Intermountain Health
Murray, Utah, United States, 84107
Actively Recruiting
37
University of Utah Health
Salt Lake City, Utah, United States, 84108
Actively Recruiting
38
Sentara Health Research Center
Norfolk, Virginia, United States, 23507
Actively Recruiting
39
Carilion Clinic
Roanoke, Virginia, United States, 24014
Actively Recruiting
40
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
S
Sunil Rao
CONTACT
L
Lei Lei
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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