Actively Recruiting
Pulmonary Hypertension in Left Heart Disease
Led by Mayo Clinic · Updated on 2026-03-05
3000
Participants Needed
1
Research Sites
249 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal is to compare patients with and without varying severity of pulmonary vascular disease based upon hemodynamic signatures, echocardiographic measures, and lung ultrasound, in tandem with expired gas metabolic testing and blood sampling.
CONDITIONS
Official Title
Pulmonary Hypertension in Left Heart Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients referred to the cardiac catheterization laboratory for invasive right heart catheterization for any reason.
- Left Heart Disease, defined as one or more of the following:
- Symptomatic HFpEF with normal left ventricular ejection fraction (≥50%) and objective evidence of heart failure.
- Symptomatic HFrEF with reduced ejection fraction (<50%).
- Symptomatic valvular heart disease with clinically significant aortic or mitral valve disease.
You will not qualify if you...
- Unable or unwilling to undergo noninvasive echocardiography or if it would compromise data quality.
- Pulmonary arterial hypertension (Group 1 PH), hypoxia/lung disease-related PH (Group 3), thromboembolic PH (Group 4), or miscellaneous PH (Group 5).
- Significant lung disease, hypoxemia, or lung infection.
- Amyloid or infiltrative cardiomyopathy.
- Acute myocarditis.
- Acute coronary syndrome or revascularization within 90 days.
- Use of pulmonary hypertension-specific drugs.
- Constrictive pericarditis.
- High output heart failure.
- Heart failure hospitalization within 30 days.
- Severe aortic or mitral valve stenosis.
- Unable or unwilling to exercise.
- Inadequate echocardiographic imaging windows.
- Unable or unwilling to cooperate with breath holding.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Circulatory Failure Research Team
CONTACT
B
Barry Borlaug, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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