Actively Recruiting
Pulmonary Hypertension SOLAR
Led by Bastiaan Driehuys · Updated on 2026-02-24
30
Participants Needed
1
Research Sites
246 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI). Such a signature may identify Group 3 PH responders to PAH-specific therapies. PAH's unique 129Xe MRI signature has been shown in previous studies. Past studies have lacked a pathologic "ground truth" correlate of these signatures, which could be provided by comparing them with the pathology of lung explant tissue from patients who have undergone a lung transplant. This signature could be validated in a cohort of patients with Group 3 PH in future studies.
CONDITIONS
Official Title
Pulmonary Hypertension SOLAR
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Currently on the lung transplant waiting list at Duke University Medical Center
- Pulmonary hypertension confirmed by right heart catheterization with mean pulmonary artery pressure over 20 mmHg, pulmonary vascular resistance over 3 Wood units, and pulmonary capillary wedge pressure under 15 mmHg
- Diagnosed with one of the following groups: PAH without severe lung disease or other excluded conditions; COPD without PH; COPD with PH; IPF without PH; IPF with PH
- Willing and able to give informed consent and follow study visit and protocol schedules
You will not qualify if you...
- Moderate to severe heart disease including left ventricular ejection fraction less than 45% or severe left ventricular hypertrophy
- Sarcoidosis
- Active cancer
- Sickle cell anemia
- Liver disease classified as Child-Pugh class C
- Prisoner or pregnant
- Unable to provide consent
- Conditions preventing MRI scanning such as metal in the eye, claustrophobia, or inability to lie flat
- Medical or psychological conditions that may pose undue risk or interfere with protocol compliance
AI-Screening
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Trial Site Locations
Total: 1 location
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
C
Claudia Salazar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
5
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