Actively Recruiting
Pulmonary Immune Cell-microbiome Interactions in the Healthy Lung
Led by Hvidovre University Hospital · Updated on 2025-03-17
50
Participants Needed
1
Research Sites
293 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall aim is to to provide a normal material for the composition and spatial heterogeneity of the following in the healthy lung: i) immune cell populations and their activation patterns, ii) the surrounding cytokine-chemokine milieu, including trans-compartmental fluxes of these mediators between the lung and bloodstream, and iii) the lung microbiome. Main hypotheses: * Absolute and relative immune cell counts in bronchoalveolar lavage fluid (BALF) are similar to those previously reported by other methods6,7. * No trans-compartmental flux of cytokines between the lungs and bloodstream is present, but cytokine concentrations (notably IL-6 and IL-8) vary with the immune-cell-microbiome composition. * Immune cell (mainly T cell) activation, differentiation, and gene expression patterns are expected to differ between blood and BALF in a manner that depends on the regional diversity of the pulmonary microbiome.
CONDITIONS
Official Title
Pulmonary Immune Cell-microbiome Interactions in the Healthy Lung
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women
- Age 40 to 75
You will not qualify if you...
- Immune deficiency
- Lung disease
- Active cancer or infection
- Absolute contraindications for bronchoscopy including untreated malignant arrhythmia
- Documented or suspected intracranial hypertension (intracranial pressure 65 > 15 mmHg)
- One-lung ventilation
- Severe coagulopathy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hvidovre Hospital, University of Copenhagen
Hvidovre, Denmark, 2650
Actively Recruiting
Research Team
R
Ronni Plovsing, MD, PhD
CONTACT
K
Katrine Schneider, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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