Prolonged lung cancer screening reduced 10-year mortality in the MILD trial: new confirmation of lung cancer screening efficacy.
U Pastorino, M Silva, S Sestini...
https://pubmed.ncbi.nlm.nih.gov/30937431/Actively Recruiting
Led by Case Comprehensive Cancer Center · Updated on 2026-04-13
85
Participants Needed
1
Research Sites
113 weeks
Total Duration
Researchers are evaluating pulmonary rehabilitation as a supportive treatment for people who have been diagnosed with advanced stage non-small cell lung cancer NSCLC. Many individuals with advanced NSCLC experience breathing difficulties and fatigue, which can reduce their quality of life. This study aims to understand whether pulmonary rehabilitation can improve functioning and reduce shortness of breath in these patients. It also explores challenges faced by patients and oncology care providers regarding pulmonary rehabilitation. The study has two parts. In the first part, participants are randomly assigned to one of two groups one group receives an eight-week pulmonary rehabilitation program with two sessions per week led by certified respiratory therapists, including exercise, education on physical function, nutrition, and psychosocial health the other group receives usual care, consisting of standard education on nutrition and physical activity for cancer survivors. The second part involves interviews with subsets of participants and medical care providers to identify barriers to pulmonary rehabilitation. Participants will attend study visits at the start and after eight weeks to measure changes in their functional capacity using a 6-minute walk test and report their breathing difficulties and quality of life through several validated scales. The study also tracks cancer-related adverse events reported by participants. Interviews will be conducted once between six and thirty months after enrollment to understand obstacles to pulmonary rehabilitation. The total participation duration varies with these assessments and follow-ups.
CONDITIONS
Pulmonary Rehabilitation in Advanced Lung Cancer Survivors
M
Melinda Hsu, MD, MS
P
Peronne Joseph
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Case Comprehensive Cancer Center
Lead Sponsor
United States Department of Defense
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Pulmonary Rehabilitation (8-week course) | Usual Care Education (Nutrition/Physical Activity) |
|---|---|---|
| What is this option? | An eight-week program including twice-weekly pulmonary rehabilitation sessions led by certified respiratory therapists, plus a personalized exercise prescription targeting cardiopulmonary health, physical function, and nutrition. | Standard supportive care consisting of educational materials on nutrition and physical activity for cancer survivors, published by the American Institute for Cancer Research. |
| Role in the trial | Investigational supportive intervention for improving physical function, dyspnea, and quality of life. | Comparator arm reflecting the standard education available to survivors, with no structured rehabilitation. |
| Primary use | PR is used to improve exercise capacity, reduce dyspnea, and enhance overall quality of life in adults surviving advanced NSCLC. | The usual care education arm aims to provide basic nutrition and physical activity guidance but does not include structured rehabilitation or personalized exercise. |
| How is it delivered? | Twice weekly in-person sessions over eight weeks, led by respiratory therapists, plus a tailored exercise plan to complete at home. | Patients receive publicly available educational materials, with no scheduled rehabilitation sessions or personalized exercise. |
| Evidence status | No published trial results yet for pulmonary rehabilitation in advanced NSCLC survivors; ongoing clinical investigation. Pulmonary rehabilitation is guideline-supported in chronic respiratory disease, though evidence in lung cancer populations is still evolving. | Standard education is widely available but has not shown consistent benefit without structured interventions; barriers to exercise among survivors may persist despite access to educational materials. |
| Important limitations | Participants must be clinically stable with no recent disease progression and must not have advanced cardiac or musculoskeletal contraindications. PR access may be limited by referral barriers and patient health status; benefit in advanced NSCLC is not yet established outside research settings. | Educational guidance alone often lacks personal tailoring and may not address dyspnea, fatigue, or psychosocial needs; survivors frequently encounter barriers to engaging in physical activity without structured support. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants complete an 8-week course of pulmonary rehabilitation, attending sessions twice weekly. Each session includes review of physical function, nutrition, and psychosocial health, along with an individualized exercise prescription to follow throughout the course.
Two visits per week for 8 weeks
Duration - 1 day
Participants complete outcome assessments at the end of the 8-week pulmonary rehabilitation period to evaluate changes in functional capacity, dyspnea, quality of life, and adverse events.
1 visit (in-person) at 8 weeks
Duration - One-time between 6 and 30 months
Selected participants and medical care providers participate in one-time qualitative interviews between month 6 and 30 to assess attitudes and barriers to pulmonary rehabilitation.
1 interview visit
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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Lead Sponsor
United States Department of Defense
Collaborating Sponsor