Actively Recruiting
Pulmonary Rehabilitation in Advanced Lung Cancer Survivors
Led by Case Comprehensive Cancer Center · Updated on 2026-04-13
85
Participants Needed
1
Research Sites
141 weeks
Total Duration
On this page
Sponsors
C
Case Comprehensive Cancer Center
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is for people who have previously been diagnosed with advanced stage non-small cell lung cancer (NSCLC). Many people with advanced stage NSCLC have trouble breathing and feel tired. People may be eligible for this study if they have advanced stage NSCLC and feel short of breath some of the time. NSCLC survivors may also experience things like fatigue and a lower quality of life. Pulmonary rehabilitation is a type of supportive treatment that may improve these symptoms. This study has two parts. The first part is a randomized trial where half of the participants receive eight weeks of pulmonary rehabilitation. The other half of participants do not do pulmonary rehabilitation and instead receive the treatment that their doctors would normally recommend. The purpose of this part of the research study is to understand if pulmonary rehabilitation can help people with advanced stage NSCLC have better functioning and less shortness of breath. The other part of the research study is an interview study. The purpose of doing interviews is to understand any challenges or obstacles that people with advanced stage NSCLC may have regarding pulmonary rehabilitation, as well as oncology care providers have with their participants going to pulmonary rehabilitation.
CONDITIONS
Official Title
Pulmonary Rehabilitation in Advanced Lung Cancer Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have histologically confirmed NSCLC, Stages III or IV treated with palliative intent
- Adults 18 years of age or older
- ECOG performance status 3 or less
- No clinical or radiographic progression within the last three months
- Self-reported dyspnea with a score of 2 or higher on the modified Medical Research Council Dyspnea Scale
- Fluent in written and spoken English
You will not qualify if you...
- Receiving curative treatment with chemotherapy and radiation for locally advanced or oligometastatic NSCLC
- Evidence of clinical or radiographic progression
- Mental impairment preventing completion of study requirements
- High risk of fracture or spine instability (Mirels score 7 or higher or SINS 7 or higher)
- Class II, III, or IV heart failure by New York Heart Association classification
- History of acute coronary syndromes or coronary procedures within 6 months before radiation therapy
- Uncontrolled arrhythmias (rate-controlled atrial fibrillation stable for over 1 month may be eligible)
- Syncope
- Acute myocarditis, pericarditis, or endocarditis
- Acute pulmonary embolus or infarction within the last 3 months
- Acute thrombosis of lower extremities within the last 3 months
- Suspected dissecting aneurysm
- Pulmonary edema
- Respiratory failure
- Acute non-cardiopulmonary disorder affecting or worsened by exercise
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
M
Melinda Hsu, MD, MS
CONTACT
P
Peronne Joseph
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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