ABC of palliative care. Anorexia, cachexia, and nutrition.
E Bruera
https://pubmed.ncbi.nlm.nih.gov/9393230Actively Recruiting
Phase Not Applicable
Age: 18Years - 70Years
All Genders
ID02978521
Effect of a Pulmonary Rehabilitation Program on Muscle Mass, Lung Function, Inflammation, and Survival in Advanced Non-small-cell Lung Cancer
Led by Instituto Nacional de Cancerologia de Mexico · Updated on 2026-04-08
94
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Lung cancer is often diagnosed at advanced stages and remains the leading cause of cancer-related deaths worldwide. Many patients with advanced lung cancer experience cancer cachexia, a condition that leads to loss of muscle and fat mass, increasing risks of complications, longer hospital stays, and poorer survival. This research aims to explore how a pulmonary rehabilitation program affects lung function, muscle mass, exercise tolerance, inflammation, quality of life, and overall survival in patients with advanced non-small-cell lung cancer who are receiving chemotherapy or targeted therapies. Participants will be randomly assigned to either an intervention group or a control group. Those in the intervention group will attend 12 pulmonary rehabilitation sessions lasting about 60 minutes each over 4 to 6 weeks, including breathing exercises, resistance training with ergometers and treadmills, progressing based on individual tolerance. The control group will receive information and advice on physical activity. Both groups will have nutritional assessments and interventions if needed. During the study, participants will undergo assessments of lung function, muscle mass, inflammatory response, exercise tolerance, quality of life, anxiety, and depression before and after the 12 rehabilitation sessions. Researchers will monitor these outcomes to evaluate the effects of the pulmonary rehabilitation program. The total participation period includes these 6 weeks of sessions with follow-up assessments to measure changes and overall survival.
CONDITIONS
Brief Title
Pulmonary Rehabilitation in Advanced Non-small Cell Lung Cancer Patients
Who Can Participate
Age: 18Years - 70Years
All Genders
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of advanced non-small-cell lung cancer
- Good performance status (ECOG 0-1)
- Life expectancy greater than 12 weeks
- Eligible to receive chemotherapy or tyrosine kinase inhibitors
- Recent electrocardiogram without arrhythmia
You will not qualify if you...
- Symptomatic brain metastasis
- Uncontrolled pain with Visual Analog Scale greater than 5
- Uncontrolled hypertension above 140/100 mmHg
- Regular moderate to intense physical activity at least 3 days per week
- Not living in Mexico City or unable to attend therapy sessions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 4 to 6 weeks
Participants in the intervention group receive pulmonary rehabilitation consisting of 12 sessions over 4 to 6 weeks. Sessions include breathing techniques, resistance training on an ergometer, and treadmill training. Control group participants receive information and recommendations on physical activity. Both groups undergo nutritional assessment and intervention as needed.
12 sessions (in-person) over 4 to 6 weeks, 2-3 sessions per week
Trial Site Locations
Total: 1 location
1
Instituto Nacional de Cancerología
Mexico City, Mexico City, Mexico, 14080
Actively Recruiting
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Research Team
O
Oscar Arrieta
D
Diana Flores
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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