Actively Recruiting
Pulmonary Vein Isolation (PVI) Combined With Renal Denervation (RDN) in Atrial Fibrillation (AF) and Hypertension (HTN)
Led by The First Affiliated Hospital of Xiamen University · Updated on 2024-03-13
120
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The close relationship between the increase of sympathetic tension, AF, and HTN cannot be ignored. In addition, the significant failure rate of PVI (20-50%) in the treatment of AF makes it very necessary to explore the effect of RDN on AF. Therefore, this study aims to compare the effects and safety of PVI alone and PVI combined with RDN with AF combined with HTN, which will open a new chapter for PVI combined with RDN in the treatment of AF.
CONDITIONS
Official Title
Pulmonary Vein Isolation (PVI) Combined With Renal Denervation (RDN) in Atrial Fibrillation (AF) and Hypertension (HTN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Clinic blood pressure of 140/90 mmHg or higher, or 24-hour average blood pressure of 135/85 mmHg or higher
- Diagnosis of atrial fibrillation by ECG
- Signed informed consent and approval by the Ethics Committee of the First Affiliated Hospital of Xiamen University
You will not qualify if you...
- Pregnant or breastfeeding women
- Unsuitable for ablation due to renal artery conditions such as stenosis over 50%, aneurysm, prior renal artery surgery, malformation, artery diameter less than 4 mm, or treatable segment length less than 20 mm
- Having only one kidney or a history of kidney transplantation
- Previous renal arterial intervention or renal denervation
- Secondary or pseudo hypertension except renal parenchymal hypertension
- Malignant tumors or end-stage diseases
- Severe peripheral vascular disease or abdominal aortic aneurysm
- Left atrium larger than 55 mm
- Bleeding tendency or blood system diseases
- Acute coronary syndrome within the last two weeks
- Acute or severe systemic infection
- Drug or alcohol dependence
- Refusal to sign informed consent
- Other conditions unsuitable for PVI and RDN
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
the first affiliated hopital of Xiamen University
Xiamen, Fujian, China, 361003
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here