Lung Volume Changes in Preterm Infants Using Synchronized Noninvasive Positive Pressure Ventilation

What this Trial Is About

Researchers are studying lung volume changes in preterm infants receiving synchronized noninvasive positive pressure ventilation sNIPPV for respiratory distress syndrome and other lung conditions. This observational study aims to understand how synchronized breaths affect lung aeration compared to non-synchronized or backup inflations, using Electrical Impedance Tomography EIT to measure these effects. The goal is to clarify the intrapulmonary mechanisms behind sNIPPVs benefits in preventing respiratory failure. Participants will have an EIT belt and pulse oximeter sensor attached during a nursing care session. The study involves switching ventilation modes between sNIPPV and continuous positive airway pressure CPAP to record lung function during spontaneous, synchronized, non-synchronized, and backup breaths. Measurements are taken at multiple predefined timepoints over a 180-minute recording period, with ventilator settings held constant throughout. During the study, lung volume changes, regional aeration, heart rate, oxygen levels, and lung ultrasound scores will be continuously monitored and analyzed. The EIT device records lung impedance and ventilation distribution to assess breathing patterns. Data collection concludes after the next nursing session when sensors are removed. This process helps researchers evaluate how different ventilation modes impact lung function in very young preterm infants.

Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation