Actively Recruiting
Intrapulmonary Volume Changes During Synchronized Noninvasive Positive Pressure Ventilation in Preterm Infants
Led by University of Zurich · Updated on 2025-12-09
27
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
U
University Hospital, Zürich
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying lung volume changes in preterm infants receiving synchronized noninvasive positive pressure ventilation (sNIPPV) for respiratory distress syndrome and other lung conditions. This observational study aims to understand how synchronized breaths affect lung aeration compared to non-synchronized or backup inflations, using Electrical Impedance Tomography (EIT) to measure these effects. The goal is to clarify the intrapulmonary mechanisms behind sNIPPV's benefits in preventing respiratory failure. Participants will have an EIT belt and pulse oximeter sensor attached during a nursing care session. The study involves switching ventilation modes between sNIPPV and continuous positive airway pressure (CPAP) to record lung function during spontaneous, synchronized, non-synchronized, and backup breaths. Measurements are taken at multiple predefined timepoints over a 180-minute recording period, with ventilator settings held constant throughout. During the study, lung volume changes, regional aeration, heart rate, oxygen levels, and lung ultrasound scores will be continuously monitored and analyzed. The EIT device records lung impedance and ventilation distribution to assess breathing patterns. Data collection concludes after the next nursing session when sensors are removed. This process helps researchers evaluate how different ventilation modes impact lung function in very young preterm infants.
CONDITIONS
Brief Title
Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent by one or both parents or legal guardians
- Gestational age at birth less than 30 0/7 weeks
- Infants receiving synchronized noninvasive positive pressure ventilation (sNIPPV)
- Chronological age below 4 weeks
You will not qualify if you...
- Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects)
- Too ill or unstable according to the treating physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 nursing care session
Participants will have an Electrical Impedance Tomography (EIT) belt and a pulse oximeter sensor attached during the final nursing care session before the study begins.
1 visit (in-person)
Duration - 3 hours
Participants will be observed continuously while receiving synchronized noninvasive positive pressure ventilation (sNIPPV). Lung volume changes and respiratory parameters will be recorded over a 180-minute period including baseline spontaneous breathing periods using CPAP.
Continuous monitoring during 1 visit
Trial Site Locations
Total: 1 location
1
University Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
C
Christoph M Rüegger, MD
C
Claudia Knöpfli
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here