Actively Recruiting
Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation
Led by University of Zurich · Updated on 2025-12-09
27
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
U
University Hospital, Zürich
Collaborating Sponsor
AI-Summary
What this Trial Is About
Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.
CONDITIONS
Official Title
Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent by one or both parents or legal guardians
- Gestational age at birth < 30 0/7 weeks
- Infants on sNIPPV respiratory support
- Below 4 weeks chronological age
You will not qualify if you...
- Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects)
- Too ill or unstable in the opinion of the treating physician
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
C
Christoph M Rüegger, MD
CONTACT
C
Claudia Knöpfli
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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