Actively Recruiting
Pulsatile Flushing Technique in Reducing Blockage of T-CVAD for Haemodialysis Patients
Led by Queen Elizabeth Hospital, Hong Kong · Updated on 2026-05-11
591
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
Sponsors
Q
Queen Elizabeth Hospital, Hong Kong
Lead Sponsor
K
Kwong Wah Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study investigates the effectiveness of pulsatile flushing techniques in reducing blockage in Tunnelled Central Venous Access Device (T-CVAD) among patients undergoing haemodialysis (HD) treatment at multiple renal centres within the Hospital Authority (HA) in Hong Kong. With limitation in single service protocol for each cluster of renal units, it is designed as a prospective, parallel, cluster non-randomised controlled trial involving 591 patients from 14 renal units. In order to identify the most effective flushing technique for T-CVAD maintenance, survival analysis on clinical effectiveness, in terms time-to-event blockage of the T-CVAD, among three trial arms: 1) Intervention Group A (IG-A) using pulsatile flushing technique with 0.4 second pause time interval; 2) Intervention Group B (IG-B) using pulsatile flushing technique with 1 second pause time interval; 3) Control Group (Con) using standard bolus flushing technique. The findings facilitate development of best practice for T-CVAD maintenance, optimise T-CVAD maintenance protocols, and ultimately improve patient outcomes. This groundbreaking study is expected to signify substantial progression in the nursing management of HD and T-CVAD.
CONDITIONS
Official Title
Pulsatile Flushing Technique in Reducing Blockage of T-CVAD for Haemodialysis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing haemodialysis treatment with Tunnelled Central Venous Access Device (T-CVAD) at Hospital Authority renal centers
- Able to understand spoken and written Chinese or English
You will not qualify if you...
- Patients with Non-Tunnelled Central Venous Access Device (NT-CVAD)
- Temporary dysfunctions resolved with repositioning (e.g., catheter kicking)
- Confirmed fibrin sheath occlusion needing surgical intervention
- Non-thrombotic occlusion caused by mechanical issues (e.g., catheter malposition)
- Patients who declined or are unable to provide written informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Queen Elizabeth Hospital
Kowloon, Hong Kong
Actively Recruiting
Research Team
S
SUNG Ka Ming Dorothy, KCC NC (Renal Care)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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