Study of Pulsed Field Ablation Using Endoscopic Electroporation to Treat Colorectal Polyps

What this Trial Is About

Researchers are investigating the use of electroporation, a technique applying small electric pulses to tissue, in treating colorectal polyps. This observational pilot study aims to evaluate the safety, effectiveness, and feasibility of pulsed field ablation PFA for removing these polyps. The study is important because colorectal cancer often develops from polyps, and treating them early may help prevent cancer progression. Kings College Hospital is conducting the research using this less invasive method compared to traditional surgeries. Participants will receive treatment with the EndoVE device, which uses vacuum-assisted endoscopic contact combined with electrical pulses from the ePORE electroporation generator during colonoscopy. The electrical field targets the polyp tissue to induce cell death. The procedure is done under sedation, typically on the same day with short hospital observation. Larger polyps may require multiple pulse applications to ensure full coverage. Follow-up colonoscopies occur around 6 weeks after treatment, with possible additional treatment or standard removal if needed. During the study, participants will have clinical reviews and colonoscopies at 6 weeks, 6 months, and 5 years after initial treatment to monitor polyp response and safety. Biopsies may be taken during follow-ups under sedation to check for remaining disease. Researchers will assess treatment side effects, polyp removal success, recurrence, patient satisfaction, and quality of life. The primary outcome focuses on adverse events within 6 months, with multiple secondary outcomes evaluating efficacy and patient well-being over time.

PULSed Field ablAtion of coloRectal Polyps