Actively Recruiting
PULSed Field ablAtion of coloRectal Polyps
Led by King's College Hospital NHS Trust · Updated on 2026-03-03
30
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
Sponsors
K
King's College Hospital NHS Trust
Lead Sponsor
M
Mirai Medical
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the role of electroporation (the use of small electric pulses applied to tissue) in the treatment (ablation) of colorectal polyps. The main questions to answer in this pilot phase of the study are: 1. The safety of pulsed field ablation (PFA) for the removal of colorectal polyps 2. The efficacy and feasibility of PFA in the treatment of colorectal polyps using metrics such as treatment coverage, treatment time, post treatment fibrosis, post treatment recurrence and patient satisfaction
CONDITIONS
Official Title
PULSed Field ablAtion of coloRectal Polyps
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years of age
- Able to review and understand the consent form
- Able to provide written informed consent
- Have at least one polyp (treatment naive, recurrent, or residual) larger than 5 mm located distal to the splenic flexure
- Polyp(s) classified as Type 1 or Type 2 by NICE or JNET classification
- World Health Organization (WHO) performance status 2 or less
- Life expectancy of at least 6 months
You will not qualify if you...
- Under 18 years of age
- Incapacitated, unconscious, or from a vulnerable population
- Pregnant or breastfeeding
- Unable to provide informed consent
- Have complex or challenging polyps (larger than 20 mm, flat or bulky, extending beyond 2 haustra folds or over 1/3 of the lumen, located in right colon proximal to splenic flexure or near ileocecal valve, hepatic or splenic flexure, or dentate line)
- Polyps classified as NICE Type 3, JNET Type 3, or Kudo Vi pit pattern
- High risk polyps as per British Society of Gastroenterology (BSG) category C
- Have five or more polyps
- Grossly inflamed colonic mucosa with bleeding or ulcers
- Implanted colonic stents
- Polyposis syndromes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
King's College Hospital
London, United Kingdom, SE5 9RS
Actively Recruiting
Research Team
A
Ademola A Adeyeye, MBBS,MSc,FRCS,FEBS, FMAS, PGDE
CONTACT
A
Amyn Haji, MA,MBBChir,MSc,MD,FRCS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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