Actively Recruiting
Pupillometry in Delayed Sleep Wake Phase Disorder
Led by Northwestern University · Updated on 2026-04-08
220
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. The main questions it aims to answer is: Are there differences in the light response in patients with delayed sleep-wake phase disorder? Does citalopram increase melatonin suppression in patients with delayed sleep-wake phase disorder? Participants will complete activity and melatonin testing at home to determine their circadian timing. This will be followed by an eye test looking at the pupil response to different light stimuli. A subset of participants will complete two inpatient admissions where melatonin levels will be sampled and they will be exposed to a bright light. During one round of testing they will receive a placebo and in the other round of testing they will take a single dose of citalopram, a selective serotonin reuptake inhibitor.
CONDITIONS
Official Title
Pupillometry in Delayed Sleep Wake Phase Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with delayed sleep-wake phase disorder
You will not qualify if you...
- Use of medications known to alter pupil diameter
- History of eye disease or eye surgery
- Unstable medical or psychiatric condition
- Shift work or self-imposed irregular sleep schedules
- Caffeine consumption greater than 400 mg per day
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
S
Sabra Abbott, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here