Actively Recruiting
PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration Samples
Led by Medical College of Wisconsin · Updated on 2026-03-05
84
Participants Needed
2
Research Sites
404 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an open-label, phase II study in patients with resectable and borderline resectable pancreatic cancer.
CONDITIONS
Official Title
PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration Samples
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have suspicion of pancreatic adenocarcinoma and plan for endoscopic biopsy or agree to additional biopsy for research
- Be 18 years of age or older
- Able to provide informed consent or have a legally authorized representative
- Histologically confirmed pancreatic adenocarcinoma
- Eastern Cooperative Group (ECOG) performance status less than 2
- Clinical stage consistent with resectable or borderline resectable pancreatic adenocarcinoma based on CT or MRI
- Adequate organ and bone marrow function, including specified leukocyte, neutrophil, hemoglobin, platelet counts, creatinine clearance, and liver enzyme levels
- Female patients must be postmenopausal, surgically sterile, or have a negative pregnancy test and use contraception before and during study treatment
- Male patients must be surgically sterile or use barrier contraception during and after study treatment
You will not qualify if you...
- Received chemotherapy and/or radiation within three years prior to enrollment
- History of another malignancy within three years except certain cured skin, cervical, or prostate cancers
- Uncontrolled serious comorbidities including infections, heart failure, unstable angina, arrhythmias, psychiatric illness, or excessive obesity (BMI >55)
- Known HIV, hepatitis B, or hepatitis C infection
- Pregnant or breastfeeding or childbearing potential without contraception four weeks prior to treatment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
HonorHealth Medical Group
Scottsdale, Arizona, United States, 85258-4566
Actively Recruiting
2
Froedtert & the Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
M
Medical College of Wisconsin Cancer Center Clinical Trials Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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