Actively Recruiting
Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial
Led by Lawson Research Institute of St. Joseph's · Updated on 2025-08-01
60
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
L
Lawson Research Institute of St. Joseph's
Lead Sponsor
W
Western University, Canada
Collaborating Sponsor
AI-Summary
What this Trial Is About
Long COVID is a complex condition that affects approximately 1.4 million Canadians following SARS-CoV-2 infection. Fatigue is the most common symptom of Long COVID. This feasibility trial will evaluate a new rehabilitation program called COVIDEx for treating fatigue after COVID-19, and compare its effectiveness to the standard treatment currently used. The experimental treatment group will receive an 8-week multi-modal rehabilitation program with two 50-minute sessions per week. 60 participants will be recruited, randomly assigned to the COVIDEx program or standard of care (SoC) and followed for 24 weeks.
CONDITIONS
Official Title
Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults of at least 18 years of age
- Able to provide informed consent
- Can speak and understand English
- Documented history of SARS-CoV-2 infection (positive PCR/antigen test during acute illness or clinical diagnosis by physician during or after the acute illness)
- Fatigue symptoms within 3 months of COVID-19 infection, lasting at least 2 months
- Fatigue symptoms cannot be explained by an alternative diagnosis
- Fatigue symptoms may be new onset following initial recovery from an acute COVID-19 infection or persist from the initial illness
- Fatigue symptoms may have an episodic nature, fluctuate or relapse over time
- Minimal functional capability: able to walk 10-15 minutes and be recovered within 30-60 minutes or without significant post-exertional malaise (PEM)
- Has applicable technology to access Microsoft Teams and Webex (i.e., computer, laptop, tablet)
You will not qualify if you...
- Active SARS-CoV-2 infection
- Pre-existing physical, cognitive, and/or mental health conditions that make exercise contraindicated, consent unattainable, or that cause symptoms similar to those seen in post COVID-19 (e.g., major neurocognitive disorder, schizophrenia, chronic fatigue syndrome) that could affect data
- Inability to follow study procedures
- Pregnant and/or breastfeeding
- Received investigational agents as part of a separate study within 30 days of the screening visit
- Has any type of metal bodily implant in head or heart (i.e., pins, plates, pacemakers)
- Current participation in other studies related to COVID-19, exercise, and/or fatigue interventions OR participation within 30 days of the screening visit
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Parkwood Hospital - St. Joseph's Health Care London
London, Ontario, Canada, N6C 0A7
Actively Recruiting
Research Team
N
Nicole Billias, BPH, CPT
CONTACT
A
Arden Lawson, BMSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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