What is this study trying to find out about septic shock?

This study is examining how a particular blood gas ratio (PvCO2-PaCO2/CaO2-CvO2) changes during the early phase of septic shock and how it compares to arterial lactate, a traditional marker of anaerobic metabolism. Researchers aim to understand if this ratio can help predict patient outcomes. The study is sponsored by Avicenna Military Hospital.

Who may be eligible for this septic shock clinical trial?

Adults aged 18 or older with septic shock defined by persistent low blood pressure needing vasopressors and elevated lactate levels despite fluids may be eligible. Both men and women can participate. Central venous access in the superior vena cava is required. Please review eligibility criteria for more details.

Is there any cost to participate in this septic shock clinical trial?

Study-related care, including all blood tests and monitoring, is provided at no cost. However, any personal travel or related expenses are not guaranteed to be covered. Participants should plan accordingly.

Actively Recruiting

Age: 18Years +

All Genders

ID07096284

Prognostic Value and Kinetics of the PvCO2-PaCO2CaO2-CvO2 Ratio Compared to Arterial Lactate in the Initial Phase of Septic Shock

Led by Avicenna Military Hospital · Updated on 2026-03-31

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are assessing a specific blood gas ratio, the PvCO2-PaCO2CaO2-CvO2, as a potential marker of anaerobic metabolism in patients experiencing acute circulatory failure caused by septic shock. The study compares the changes in this ratio to the classic marker of anaerobic metabolism, arterial lactate, during the early phase of septic shock. This observational research is conducted to better understand the prognostic value of this ratio in critical illness. Adult patients diagnosed with septic shock, characterized by persistent low blood pressure requiring vasopressors and elevated lactate levels despite adequate fluid treatment, will be enrolled. Participants will undergo serial blood tests to measure arterial and venous blood gases and arterial lactate at several time points baseline H0, 2 hours, 6 hours, 12 hours, and 24 hours after inclusion. The study involves calculating the PvCO2-PaCO2CaO2-CvO2 ratio using specific formulas based on oxygen content in the blood. Participants will be closely monitored through these blood assessments to track the kinetics of the studied ratio and compare it to arterial lactate levels. The main outcome measured is the prognostic value of the PvCO2-PaCO2CaO2-CvO2 ratio over the first 24 hours following study inclusion. This monitoring helps researchers understand how this ratio behaves during the early septic shock phase and its potential to guide patient care. The study is sponsored by Avicenna Military Hospital and will continue until June 2026.

CONDITIONS

Brief Title

The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) 265 mmHg and lactatemia > 2 mmol/L despite adequate fluid resuscitation
Sepsis defined by suspected or confirmed infection with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological)

You will not qualify if you...

Absence of central venous access
Central venous access not positioned in the superior vena cava (e.g., femoral access)

Research Team

Younes Aissaoui Professor of critical care medicine

Ayoub Belhadj Professor of critical care medicine

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