Actively Recruiting
Pyrotinib Combined With Dalpiciclib Combined With Letrozole in ER-positive and HER2-positive Advanced Breast Cancer
Led by Zhejiang Cancer Hospital · Updated on 2025-06-11
63
Participants Needed
1
Research Sites
360 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a a multicenter Phase II clinical study investigating efficacy of pyrotinib combined with dalpiciclib combined with letrozole in ER-positive and HER2-positive advanced breast cancer patients. The sample size is 63.
CONDITIONS
Official Title
Pyrotinib Combined With Dalpiciclib Combined With Letrozole in ER-positive and HER2-positive Advanced Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily joined the study, signed informed consent, and have good compliance
- Female participants who are postmenopausal or premenopausal/perimenopausal aged 18 to 75 years
- Recurrent or metastatic breast cancer confirmed by histopathology with positive ER and HER2 expression
- At least one extracranial measurable lesion meeting RECIST 1.1 criteria
- At most one previous trastuzumab-containing systemic therapy for recurrent metastatic breast cancer
You will not qualify if you...
- Untreated central nervous system metastasis
- Bilateral breast cancer, inflammatory breast cancer, or latent breast cancer
- Previous treatment with any CDK4/6 inhibitors
- Inability to swallow, intestinal obstruction, or other factors affecting drug absorption
- Other malignancies within 5 years or at the same time except cured basal cell carcinoma of the skin and carcinoma in situ of the cervix
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
Z
Zhiqiang Xiao, Master
CONTACT
Z
Zhiqiang Xiao
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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