Actively Recruiting
QOL and Sarcopenia in Patients With Ascites
Led by Abramson Cancer Center at Penn Medicine · Updated on 2025-08-29
70
Participants Needed
1
Research Sites
175 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Clinical data regarding quality of life in patients with refractory ascites is limited and preceded the development of newer questionnaires that may be more robust. One primary objective of this study is to study changes in quality in life in a prospective fashion using newer general and ascites-specific quality of life survey instruments specific to benign and malignant etiologies. Sarcopenia is a condition that is prevalent in cancer and cirrhosis. Current data is retrospective and associative, evaluating heterogeneous patient populations at different stages within the timeline of refractory ascites. The other primary objective of this study is to study sarcopenia in a prospective fashion and to understand its kinetics once a patient develops refractory ascites. Prospectively-obtained measures of deterioration in patient-reported outcomes and in muscle mass will form the basis for the next stage of investigation of interventions to mitigate these declines.
CONDITIONS
Official Title
QOL and Sarcopenia in Patients With Ascites
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Eastern Cooperative Oncology Group (ECOG) performance score less than 3
- Refractory ascites due to cirrhosis or malignancy requiring more than one therapeutic paracentesis within a 6 week period in the past 3 months
- Ability to give informed consent
You will not qualify if you...
- Life expectancy less than 3 months
- Inability to participate in neuropsychological tests or questionnaires
- Pregnant or nursing women
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Michael C Soulen, MD
CONTACT
K
Kathleen Thomas, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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