Actively Recruiting
QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
Led by Anna Evans Phillips · Updated on 2025-12-18
500
Participants Needed
2
Research Sites
453 weeks
Total Duration
On this page
Sponsors
A
Anna Evans Phillips
Lead Sponsor
J
Johns Hopkins University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain patterns in patients with Chronic Pancreatitis (CP). QST uses a specific series of standardized stimulations to map the pain system. QST has the potential to change and improve the treatment paradigm for patients with CP and may eventually be able to predict response to invasive CP therapies.
CONDITIONS
Official Title
QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects are 18 years or older.
- Subjects with no pancreatic disease and no abdominal pain or diagnosed with functional dyspepsia.
- Subjects diagnosed with Indeterminate CP (Cambridge 1 or 2) with abdominal pain but no prior acute pancreatitis or with acute/recurrent acute pancreatitis recovered and ongoing abdominal pain.
- Subjects with confirmed Chronic Pancreatitis (Cambridge 3 or 4) on CT or MRI.
- Subjects with prior diagnosis of Sphincter of Oddi Dysfunction Type 1 or 2.
- Subjects must be able to read and understand study information.
- Subjects must provide signed informed consent.
- Subjects willing and able to comply with scheduled visits, questionnaires, and study procedures.
- Subjects with abdominal pain suspected to be pancreatic in origin with intensity above 3 on visual analogue scale and chronic pain (pain ≥ 3 days per week for at least 3 months).
You will not qualify if you...
- Subjects with medical or surgical conditions important for the study as judged by the investigator.
- Subjects with painful conditions preventing distinction of pancreatic pain from other chronic pain.
- Subjects known to be pregnant at enrollment.
- Subjects who have had prior surgical intervention on the pancreas.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Johns Hopkins Medical Institutions
Baltimore, Maryland, United States, 21287
Actively Recruiting
2
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
A
Anna Evans-Phillips, MD
CONTACT
A
Apsara Mishra
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
4
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