Actively Recruiting
Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies
Led by M.D. Anderson Cancer Center · Updated on 2026-04-15
400
Participants Needed
1
Research Sites
556 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study examines the quality of life in patients with monoclonal gammopathy of unknown significance and smoldering multiple myeloma. Collecting quality of life information from patients may help doctors learn more about the most common symptoms and concerns patients with monoclonal gammopathy of unknown significance and smoldering multiple myeloma may have.
CONDITIONS
Official Title
Quality of Life in Patients With Asymptomatic Monoclonal Gammopathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with monoclonal gammopathy of unknown significance aged 18 years or older.
- Serum monoclonal protein less than 3 g/dL or urinary monoclonal protein less than 500 mg per 24 hours and clonal bone marrow plasma cells less than 10%.
- No myeloma defining events or amyloidosis.
- OR patients with smoldering multiple myeloma aged 18 years or older.
- Serum monoclonal protein 3 g/dL or higher or urinary monoclonal protein 500 mg or higher per 24 hours and/or clonal bone marrow plasma cells 10-60%.
- No myeloma defining events or amyloidosis.
- Patients must be enrolled in clinical trials for SMM or MGUS at MD Anderson Cancer Center.
- Patients must speak English or Spanish.
You will not qualify if you...
- Evidence of myeloma defining events or biomarkers of malignancy including hypercalcemia, renal insufficiency, anemia, bone lesions, clonal bone marrow plasma cells 60% or higher, involved:uninvolved serum free light chain ratio 100 or higher, or more than 1 focal lesion on MRI.
- Plasma cell leukemia.
- Presence of cognitive impairment or delirium as determined by the primary clinician.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
M
Melody Becnel, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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