Actively Recruiting
QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers
Led by Ruth Chimenti · Updated on 2025-10-07
120
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
Sponsors
R
Ruth Chimenti
Lead Sponsor
N
National Center for Complementary and Integrative Health (NCCIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is to create a test that can accurately find and measure the problem areas in muscle and fascia tissue, also known as myofascial pain. The hypothesis is that a combination of imaging findings will be able to detect when myofascial pain is present. The goal is to improve management of myofascial pain by making better tools to find changes in the muscle and fascia tissues for a more personalized treatment. This project was funded by the HEAL initiative (https://heal.nih.gov/).
CONDITIONS
Official Title
QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of plantar fasciitis
- Plantar fasciitis pain lasting 3 months or more
- Plantar fasciitis pain severity of 3 or higher on a 10-point scale
- Clinical diagnosis of insertional Achilles tendinopathy
- Achilles tendinopathy pain lasting 3 months or more
- Achilles tendinopathy pain severity of 3 or higher on a 10-point scale
- Control participants matched by age, sex, and BMI to patient groups
You will not qualify if you...
- Younger than 18 years of age
- History of invasive procedures to the foot or ankle on the side affected
- History of lower extremity injections, dry needling, or EPAT/ESWT in the past 3 months on the side affected
- Contraindications for MRI such as non-MR compatible implants, claustrophobia, inability to stay still for 1 hour, or body size too large for the scanner
- Clinically unstable medical or psychiatric conditions
- Pregnant or possibly pregnant
- Co-morbidities affecting musculoskeletal imaging, including rheumatoid arthritis, spondyloarthropathy, gout, uncontrolled diabetes, diabetic neuropathy, neuromuscular diseases, connective tissue disorders, osteoarthritis of foot or ankle, foot or ankle fractures, recent infections, familial hypercholesterolemia, neoplasms, or plantar fibromatosis
- Control group only: Persistent or recurrent leg pain in past 6 months
- Plantar fasciitis and Achilles tendinopathy groups only: Other heel or foot pain causes or co-occurring plantar fasciitis and Achilles tendinopathy (for Achilles group)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
J
Jing Danielson, DDS
CONTACT
J
Jessica Danielson, DDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here