Actively Recruiting
Quantifying Systemic Immunosuppression to Personalize Cancer Therapy
Led by Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Updated on 2025-05-02
1000
Participants Needed
1
Research Sites
251 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Serpentine (Stratify cancER PatiENTs by ImmuNosupprEssion) project, represents the most consistent effort so far attempted to translate MDSC into clinical practise by producing an off-the-shelf compliant assay for quantifying these cells in peripheral blood.
CONDITIONS
Official Title
Quantifying Systemic Immunosuppression to Personalize Cancer Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically documented diagnosis of metastatic or locally advanced melanoma, hormone-refractory breast cancer, renal cell carcinoma, urinary bladder cancer, squamous cell carcinoma of the head and neck, small cell carcinoma, or non-small cell lung cancer; stage III resectable NSCLC also included
- Willingness and ability to comply with the study protocol
- Willingness and ability to provide an adequate archival Formalin-Fixed Paraffin-Embedded (FFPE) tumor sample for exploratory biomarker analysis
- Age between 18 and 90 years at the time of recruitment
- ECOG Performance Status of 2 or lower
- Understanding and signing of informed consent
- Agreeing to participate in the socio-economic and psychological survey
You will not qualify if you...
- Known history of HIV infection
- Serious neurological or psychiatric disorders
- Pregnancy or lactation
- Inability or unwillingness to provide written informed consent
- Inability or unwillingness to be regularly followed up at the same center
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy, 20033
Actively Recruiting
Research Team
L
Licia Rivoltini
CONTACT
P
Paola Frati
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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