Actively Recruiting
Quantitative Pupillometry in Brain Injury Children : Variation After Osmotherapy
Led by University Hospital, Grenoble · Updated on 2025-04-02
90
Participants Needed
2
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Intracranial hypertension (ICH) is a common and serious complication in children admitted to pediatric intensive care units. It is primarily caused by traumatic brain injury but can also result from brain malformations, brain tumors, or neuro-meningeal infections. Rapid identification of ICH in acute settings is crucial to ensure prompt management and mitigate potential consequences, such as severe neurological sequelae or death. The assessment of the pupillary light reflex is one of the key clinical parameters used to identify ICH in children with neurological injuries. This clinical sign is correlated with neurological prognosis. During an episode of ICH, regardless of the underlying cause, the oculomotor nerve becomes compressed between the midbrain and the temporal lobe, leading to anisocoria (unequal pupil sizes) and loss of pupillary reactivity. Other factors, such as episodes of ischemia or hypoperfusion in the midbrain, can also contribute to decreased pupillary reactivity.
CONDITIONS
Official Title
Quantitative Pupillometry in Brain Injury Children : Variation After Osmotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized in a pediatric intensive care unit or neurosurgical intensive care unit
- Inclusion within 24 hours of ICU admission
- Clinically suspected intracranial hypertension with disorders of consciousness, abnormal transcranial Doppler, symptoms, or poor cerebral perfusion pressure
- Osmotherapy is prescribed for intracranial hypertension
You will not qualify if you...
- Presence of current or past eye damage
- Refusal by parents or child
- Not affiliated with the social security system
- Protected persons such as those under guardianship, curatorship, pregnant or breastfeeding women, persons deprived of liberty, or under psychiatric measures
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Chu Grenoble Alpes
Grenoble, ISERE, France, 387000
Actively Recruiting
2
Grenoble Alpes University Hospital
La Tronche, France, 38700
Not Yet Recruiting
Research Team
S
Sarah SS SINTZEL STRIPPPOLI, Doctor
CONTACT
A
Angélina AP POLLET, RESEARCH NURSE
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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