Actively Recruiting
Questioning the Epidemiology of Asymptomatic TB
Led by Barcelona Institute for Global Health · Updated on 2025-12-31
6770
Participants Needed
1
Research Sites
194 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Tuberculosis (TB) remains one of the world's leading causes of morbidity and mortality. Current TB control strategies focus largely on the binary paradigm of TB, which tackle Mtb infection and the symptomatic stages of the disease as the major drivers of the TB epidemic. However, prevalence surveys have shown that about 50% of cases in which Mycobacterium tuberculosis is isolated from sputum but do not report having symptoms. Therefore, asymptomatic TB may play an important role in TB transmission. However, no field study has demonstrated direct transmission from a subclinical TB case to a confirmed secondary case. TB-QUEST is an ERC-funded epidemiological field study that aims to provide direct evidence of effective transmission from asymptomatic TB cases to their close contacts using advanced genomic methods, and to better characterize the asymptomatic stage of TB within the natural history of disease.
CONDITIONS
Official Title
Questioning the Epidemiology of Asymptomatic TB
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Documented HIV infection
- Presenting at a health facility for routine HIV care
- On ART for less than 6 months (for Study 3)
- No evidence of viral suppression (for Study 3)
- Documented CD4 count greater than 350 copies/ul (for Study 3)
- TB-suggestive x-ray (for Study 3)
- Verified absence of fever and cough through symptom trackers (for Study 3)
- All close contacts, regardless of age or HIV status, will be offered participation
You will not qualify if you...
- History of TB treatment in the last 12 months
- Pregnant women
- Refusal to provide consent for study procedures
- Contraindication to any sampling procedure required by the study
- Plans to migrate in the next 12 months (for contacts)
- Currently taking anti-tuberculosis treatment or preventive TB treatment (for contacts)
- Contacts with co-prevalent TB identified at baseline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centro de Investigação em Saúde de Manhiça (CISM)
Manhiça, Maputo Province, Mozambique
Actively Recruiting
Research Team
A
Alberto L. Garcia-Basteiro, MD
CONTACT
J
Joanna Ehrlich
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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