What this Trial Is About

Researchers are studying the effects of 3D isometric movement training in both healthy adults and adults who have impairments due to stroke. The trial aims to understand how movement skills can be trained when sensory inputs like proprioception are changed, using a three-dimensional environment. This early phase 1 study builds on previous findings in two-dimensional settings and applies these techniques to neurotypical adults and stroke survivors to compare their movement errors during different reaching tasks. Participants will use a robotic arm in a 3D visual display system to perform targeted reaching tasks. First, they will do unconstrained reaching, followed by isometric reaching where the robotic arm is fixed, and their applied forces move a simulated arm on the screen. Visual feedback is provided through a virtual avatar of their arm. The study measures the perpendicular error, which is the difference between the ideal and actual reaching paths, to compare performance under unconstrained and constrained conditions. During the study, participants will practice reaching tasks while researchers monitor their movement accuracy using the virtual reality system and robotic arm. Assessments include visual tests and cognitive screenings to ensure participants can complete the tasks. The main outcome measured is the average perpendicular error over about one year. Safety measures such as blood pressure and oxygen levels will be monitored. Participants may be followed throughout the one-year study period to observe changes in their movement performance.

R01.Aim 2.Study 1: IsoReach