Actively Recruiting
Radiation Major Hepatectomy to Selectively Treat Large Unifocal Hepatocellular Carcinoma
Led by Seoul National University Hospital · Updated on 2025-01-07
30
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The RESCUE trial is a prospective, single-arm clinical study to evaluate the efficacy and safety of ablative radioembolization using Yttrium-90. This treatment is being investigated as a potential curative approach, as well as a bridging or downstaging strategy for surgery, in patients with large hepatocellular carcinoma (greater than 8 cm) who maintain good liver function.
CONDITIONS
Official Title
Radiation Major Hepatectomy to Selectively Treat Large Unifocal Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 and over
- Diagnosis of hepatocellular carcinoma confirmed by histology or radiology (LI-RADS 4 or 5)
- No more than five liver lesions with the largest tumor diameter over 8 cm
- No vascular or bile duct invasion seen on CT or MRI
- No spread of cancer outside the liver on lung CT and abdominal imaging
- No prior treatment for liver cancer
- Child-Pugh class A liver function
- ECOG performance status of 0 or 1
- No major organ dysfunction based on recent blood tests including leukocytes, neutrophils, hemoglobin, bilirubin, platelets, INR, liver enzymes, and creatinine within specified limits
- Life expectancy greater than 3 months
- Able to understand and consent to the study
- Women of childbearing potential must not be pregnant
You will not qualify if you...
- Unsuitable for ablative radioembolization due to pre-treatment lung dose exceeding 15 Gy or severe hepatic artery-portal vein shunting
- Less than 30% of non-tumorous liver volume remaining outside the treatment area
- Planned use of immunotherapy regardless of radioembolization response
- Active cancer within the last two years
- Prior surgery or procedures involving the bile duct
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Seoul National University Hospital
Seoul, Seoul, South Korea, 03080
Actively Recruiting
Research Team
J
Jin Woo Choi, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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