Actively Recruiting
Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release
Led by Dartmouth-Hitchcock Medical Center · Updated on 2024-11-22
95
Participants Needed
1
Research Sites
393 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy
CONDITIONS
Official Title
Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 or greater with Dupuytren's Contracture
- Extension deficit greater than 10 degrees
- Unable to place the affected finger and palm flat on a table simultaneously
- Women must be post-menopausal or using contraception; pregnancy test required
- Only the first two joints on the treated hand included if having multiple injections
You will not qualify if you...
- Unsuccessful non-surgical release
- Development of an open wound during CCH injection
- Currently breastfeeding or pregnant
- Chronic muscular, neurologic, or neuromuscular disorders affecting the hands
- Under 45 years of age
- Previous radiation treatment on the hand planned for CCH injections
- Pregnant women, impaired adults, or prisoners
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Dartmouth Hitchcock
Lebanon, New Hampshire, United States, 03766
Actively Recruiting
Research Team
J
Julia S Schwarz, MD
CONTACT
L
Lance Warhold, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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