Actively Recruiting
Radical vs Local Excision for Rectal Cancer With Clinically Complete Remission
Led by National Taiwan University Hospital · Updated on 2024-09-20
180
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In the present project, the investigators plan to more accurately select the rectal cancer patients with pathological complete response (pCR) to preoperative concomitant chemoradiation therapy (CCRT), taking advantage of quantification of circulating tumor DNA (ctDNA) in addition to the current available diagnostic modalities, including CT, MRI, PET and colonoscopy. The patients with suspected pCR to CCRT will be randomized to radical surgery and local excision groups, followed by the comparison of the oncologic outcomes between two treatment methods. The investigators hypothesized that if the pCR for patients with rectal cancer after CCRT can be more accurately predicted, such patients can be safely treated with limited surgery to enhance the post-treatment life quality, in comparison with patients undergoing radical surgery.
CONDITIONS
Official Title
Radical vs Local Excision for Rectal Cancer With Clinically Complete Remission
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with rectal adenocarcinoma and completed neoadjuvant chemoradiotherapy with no cancer detected on imaging
- Physical health status within American Society of Anesthesiology (ASA) class 1 to 3
- Tumor located within 6 cm of the anal verge, accessible for transanal local excision
- Age between 18 and 75 years
You will not qualify if you...
- Circulating tumor DNA test indicates residual cancer after chemoradiotherapy
- Body mass index (BMI) greater than 40 kg/m2
- History of previous abdominal or pelvic surgery
- Abnormal liver function (bilirubin > 2.0 mg/dl), kidney function (creatinine ≥ 2.0), or blood counts (WBC < 3000, hemoglobin < 8.0, platelet < 50000) after chemoradiotherapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Jin-Tung LIANG
Taipei, Taiwan, 100
Actively Recruiting
Research Team
J
Jin-Tung LIANG, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here