Actively Recruiting
Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
Led by Mayo Clinic · Updated on 2025-06-22
128
Participants Needed
1
Research Sites
55 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.
CONDITIONS
Official Title
Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 50 and 85 years
- Moderate or greater pain on the ICOAP pain scale (A1 or B6)
- Diagnosed with primary knee osteoarthritis (ICD-10 M17.x)
- History of knee morning stiffness lasting less than 30 minutes
- History of crepitus without warmth, redness, or sudden swelling
- Tenderness on palpation at the medial or lateral joint line matching knee pain location
- No primary knee pain in pes anserine, hamstring, or gastrocnemius tendons
- Kellgren-Lawrence grade 2 or 3 on knee x-rays within the last year
- Ability to complete surveys in English
You will not qualify if you...
- Kellgren-Lawrence grade 1 or 4
- Pregnancy or women 54 years or younger with potential for pregnancy without sterilization
- History of surgery on the affected knee
- Use of injected corticosteroids within 3 months or hyaluronans within 6 months (or within 1 month if no sustained improvement)
- Knee trauma in the last year causing current pain
- History of rheumatoid arthritis, gout, pseudogout, hemarthroses, or other inflammatory arthritis in the knee
- History of symptomatic hip osteoarthritis
- History of psychosis, personality disorder, or uncontrolled affective disorder
- History of fibromyalgia
- Active cancer treatment
- Regular use of opiate analgesics, platelet-rich plasma, or acupuncture for the knees
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
F
Family Medicine Research Study Coordinators
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here