Actively Recruiting
Radiofrequency Ablation For Recurrent Parathyroid Carcinoma
Led by M.D. Anderson Cancer Center · Updated on 2026-04-14
20
Participants Needed
1
Research Sites
263 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study will be an effectiveness study. The study will include enrollment of a total of 20 patients with at least one PC lesion for ultrasound guided RFA to PC recurrence in the neck to assess the effectiveness in reducing patient's hypercalcemia. Patients will have surgically proven PC from prior parathyroidectomy and suspicious PC visible on ultrasound and request for treatment for uncontrolled hypercalcemia (Figure 1).
CONDITIONS
Official Title
Radiofrequency Ablation For Recurrent Parathyroid Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients older than 18 years with recurrent parathyroid carcinoma previously treated by surgery
- Patients not candidates for surgery or who decline surgery
- Medically fit to undergo local anesthesia with or without conscious sedation
- Able to understand and provide informed consent
- Confirmed parathyroid carcinoma by prior surgery and histopathology
- Presence of local recurrence or implant in the neck visible on ultrasound
- Presence of distant oligometastasis visible on ultrasound
- Solid nodule without macrocalcification or internal cystic degeneration
- Patients off Cinacalcet medication
- Entire selected nodule visible on ultrasound without major extension behind trachea or mediastinum
- Selected nodule suitable for medial or lateral approach
- Normal complete blood count and blood coagulation tests
- Agree to participate in the study and complete all visits and evaluations
- Negative pregnancy test for females of childbearing potential at baseline pre-procedure
You will not qualify if you...
- Patients with cardiac arrhythmia or implanted cardiac devices
- Parathyroid lesions that are surgically naive, parathyroid adenoma, or atypical parathyroid tumor
- Pregnant women
- Allergies to anesthesia medications
- Cystic nodules with less than 70% solid components
- Calcified nodules
- Nodules located within 0.5 cm of major vessels, vagus nerve, brachial plexus, or recurrent laryngeal nerve
- Patients with contralateral vocal cord paralysis
- Uncorrectable coagulopathy with prolonged PTT, elevated INR, or low platelet count below 100,000 per mm3
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT MD Anderson
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
T
Thinh Vu, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here