Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain A Randomized Double-blind Study A Novel Approach

What this Trial Is About

Researchers are evaluating the use of thermal radiofrequency ablation targeting specific sensory nerves in the knee to treat chronic pain following knee arthroplasty. This randomized double-blind trial aims to determine whether this technique can reduce pain and disability in patients who continue to experience pain at least six months after knee replacement surgery. The study focuses on sensory branches of the femoral nerve, including the infrapatellar branch of the saphenous nerve and the nerves to the medial, intermediate, and lateral vastus muscles, based on recent anatomical findings. Participants will be randomly assigned to one of two groups. One group will receive thermal radiofrequency ablation applied to the identified sensory nerves using ultrasound and neurostimulation guidance, followed by a local anesthetic injection. The procedure involves heating the nerves for 90 seconds at 80 degrees Celsius using a specialized needle. The control group will undergo the same identification and confirmation process but will receive a sham radiofrequency procedure without actual nerve ablation. Both procedures are designed to be double-blind, so neither participants nor researchers know which treatment is administered. During the study, participants' pain and disability will be assessed primarily using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) at three months post-treatment. Secondary assessments include pain intensity scales, neuropathic pain questionnaires, anxiety and depression scales, patient satisfaction, and safety monitoring for any adverse events. Participants will be followed closely to evaluate the treatment outcomes and safety over the study period, which aims to capture meaningful improvements in chronic post-knee arthroplasty pain.

Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain.