Actively Recruiting
Radiofrequency Denervation and Brain Imaging
Led by University of Aberdeen · Updated on 2024-12-24
40
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
Sponsors
U
University of Aberdeen
Lead Sponsor
N
NHS Grampian
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about changes in brain and its activity of following radiofrequency denervation treatment for chronic low back pain. The main question it aims to answer are: * report the magnitude of the brain changes following radiofrequency treatment for low back pain. * identify changes unique to radiofrequency treatment Patients with nociceptive type low back pain of moderate to severe intensity will be identified to undergo radiofrequency treatment. They will have 3 MRI scans - Baseline, after the diagnostic injections and 3 months after radiofrequency treatment. They will also fill questions relating to their pain, disability and health related quality of life.
CONDITIONS
Official Title
Radiofrequency Denervation and Brain Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Chronic moderate to severe chronic low back pain with average pain intensity of 4 or higher on an 11-point scale for at least 1 year
- Identified by clinical team as suitable for radiofrequency denervation
- Predominantly nociceptive pain with PainDetect score 12 or less
- Stable on current pain medication regimen
- Able to communicate in English
- Able and willing to provide informed consent
- Positive response to a single diagnostic medial branch block with 80% or more pain relief at 3 hours post-injection
You will not qualify if you...
- Physical condition preventing lying still for the brain scan
- Contraindications to MRI such as implantable cardiac devices
- Women who are or may be pregnant
- Significant anxiety or depression (HADS score 9 or higher)
- Clinical suspicion of an alternative diagnosis causing low back pain
- Presence of chronic primary pain conditions (e.g., fibromyalgia, chronic widespread pain, complex regional pain syndrome, chronic primary headache, orofacial pain, chronic primary visceral pain, chronic primary musculoskeletal pain)
- Presence of thoracic or neck pain
- History of previous radiofrequency denervation
- Regular use of two or more dependence-forming drugs (opioids, gabapentinoids, benzodiazepines, tricyclic antidepressants, or z-drugs)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Aberdeen Royal Infirmary
Aberdeen, Scotland, United Kingdom, AB25 2 ZN
Actively Recruiting
Research Team
S
Saravanakumar NA Kanakarajan, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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