Actively Recruiting
Radiographical, Histomorphometrical and Biomarker Analysis After Maxillary Sinus Augmentation Utilizing Xenograft Particulate Bone Graft Mixed With Parathyroid Hormone
Led by University of Baghdad · Updated on 2026-03-09
30
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aimed the to investigate the beneficial effect of combining PTH with bovine-derived bone graft bone in maxillary sinus augmentation. There is limited information available about the effect of PTH on maxillary sinus augmentation to achieve a clear understanding of PTH's efficacy in bone regeneration and bone remodelling through radiological, clinical, biomarker, histological and histomorphometric assessment . Objectives 1. Evaluation of the bone density at the planned implants sites using cone beam computed tomography (CBCT). 2. Histomorphometry examination of maxillary sinus bone to measure (bone trabeculae, connective tissue, osteoblast, osteocyte) after healing 4 months after augmentation. 3. Osteopontin as biomarker analysis for bone regeneration and osteoblast activity. 4. Evaluate the primary stability of implant in upper posterior area filled with PTH (1 34) and bovine-derived bone graft compared to bovine-derived bone graft alone.
CONDITIONS
Official Title
Radiographical, Histomorphometrical and Biomarker Analysis After Maxillary Sinus Augmentation Utilizing Xenograft Particulate Bone Graft Mixed With Parathyroid Hormone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy individuals without systemic disease or local sinus lesions affecting bone healing
- Fair to good oral hygiene
- Age 18 years or older
- Residual bone height (RBH) of 3 mm or less in the posterior maxillary ridge
- Adequate ridge width of 5 mm or more to support implant stability
- Healed planned implant insertion site
You will not qualify if you...
- Medical conditions interfering with healing or osseointegration, including uncontrolled diabetes, chemotherapy, corticosteroids, bisphosphonates, recent head and neck radiotherapy, bleeding disorders, pregnancy, thyroid hormone issues, or psychiatric disorders
- Residual bone height greater than 3 mm
- Sinus membrane thickness greater than 5 mm
- Acute or chronic maxillary sinusitis or other sinus pathologies
- Previous maxillary sinus surgery
- Heavy smoking of 20 or more cigarettes daily or alcohol abuse
- Severe bruxism or clenching (parafunctional habits)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Baghdad University
Baghdad, Iraq
Actively Recruiting
Research Team
M
Mohanad Ali Ali Shabat, Msc,PhD student in Oral surgey
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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