Actively Recruiting

Phase 1
Age: 18Years +
All Genders
NCT06199479

Radiologic Pathologic Correlation of Imaging to Distinguish True Progression From Pseudoprogression in Brain Malignancies

Led by M.D. Anderson Cancer Center · Updated on 2025-11-18

25

Participants Needed

1

Research Sites

177 weeks

Total Duration

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AI-Summary

What this Trial Is About

To learn if advanced imaging methods can tell apart true progression (the disease has actually gotten worse) from pseudoprogression (the disease appears to have gotten worse, but it actually has not).

CONDITIONS

Official Title

Radiologic Pathologic Correlation of Imaging to Distinguish True Progression From Pseudoprogression in Brain Malignancies

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participant is older than 18 years
  • Participant agrees to take part in the study and complete all required visits and evaluations
  • Participant has had prior treatment for a brain tumor and has a new suspicious imaging finding requiring biopsy consideration
  • Participant agrees to undergo imaging evaluation within 14 days before the biopsy procedure
Not Eligible

You will not qualify if you...

  • Renal failure with a GFR less than 30 mL/min/1.73m2 for gadolinium-based imaging
  • GFR less than 45 mL/min/1.73m2 for iodinated contrast agents, unless non-contrast CT is used
  • Presence of pacemakers, electronic stimulation devices, metallic foreign bodies, or other conditions not safe for MRI
  • Pregnancy
  • Claustrophobia unresponsive to oral medication
  • Allergy to iodine or gadolinium-based contrast agents (if allergy to one class, imaging with the other is allowed)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

MD Anderson Cancer Center

Houston, Texas, United States, 77030

Actively Recruiting

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Research Team

D

Dawid Schellingerhout, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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Radiologic Pathologic Correlation of Imaging to Distinguish True Progression From Pseudoprogression in Brain Malignancies | DecenTrialz