Study of Radiosurgery Effects on Hearing and Nerve Function in Adults with Vestibular Schwannoma Comparing Radiosurgery and Observation Treatments and Their Impact on Quality of Life

What this Trial Is About

Researchers are investigating the effects of stereotactic radiosurgery SRS on patients with vestibular Schwannoma, focusing on how this treatment impacts the functions of the cochlear, vestibular, gustatory, and facial nerves. The study also compares these effects with those observed in patients managed conservatively through MRI-based observation. Additionally, the study evaluates how tumor characteristics seen on radiological imaging may predict hearing preservation and vestibular function, while also assessing patients quality of life through questionnaires. The study includes both retrospective and prospective parts. The retrospective analysis reviews data from patients treated between 2014 and 2021, collecting information on demographics, treatment details, hearing and nerve function, symptoms, tumor features from MRI scans, and radiosurgery parameters. The prospective part will follow patients from now on, using standardized MRI and functional assessments to gather detailed follow-up data. Patients are grouped into those treated with stereotactic radiosurgery and those under conservative MRI-based observation. The multidisciplinary skull base tumor board independently decides treatment for each patient. Participants will undergo evaluations including hearing tests, vestibular and facial nerve function assessments, and quality of life questionnaires at baseline and during follow-up visits. These assessments occur at 1, 3, and 5 years after treatment or observation, measuring changes in hearing ability, nerve function, and patient-reported quality of life. The investigators aim to develop models predicting ototoxicity based on tumor and treatment characteristics. Data collection and monitoring will continue up to five years, with safety and function carefully tracked throughout the study period.

Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma