Actively Recruiting
Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease
Led by Western Sydney Local Health District · Updated on 2026-02-18
60
Participants Needed
1
Research Sites
111 weeks
Total Duration
On this page
Sponsors
W
Western Sydney Local Health District
Lead Sponsor
U
University of Sydney
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this randomized clinical trial is to test the efficacy of stereotactic body radiation therapy (SBRT) in treating ventricular tachycardia (VT) in patients with advanced structural heart disease. The main questions it aims to answer are: * What is the efficacy of SBRT compared to catheter ablation (CA) in achieving a ≥ 75% reduction in VT burden at 6 months * What is the comparable safety profile of SBRT vs CA Researchers will compare SBRT and CA (standard of care).
CONDITIONS
Official Title
Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with structural heart disease including ischaemic cardiomyopathy, non-ischaemic cardiomyopathy, or congenital heart disease with evidence of ventricular wall motion abnormalities, myocardial hypertrophy, or myocardial scar
- History of recurrent monomorphic ventricular tachycardia demonstrated by at least one episode treated by implantable cardioverter defibrillator (ICD), sustained VT lasting over 30 seconds, or inducible VT on electrophysiological studies
- PAINESD score of 9 or higher and/or at least moderate risk of VT recurrence or death based on the I-VT score
You will not qualify if you...
- Under 18 years of age
- Life expectancy less than 3 months
- Catheter ablation considered futile or too risky by a cardiac electrophysiologist
- Unwilling or unable to provide informed consent
- Known cardiac channelopathies such as catecholaminergic polymorphic ventricular tachycardia, long or short QT syndrome, or Brugada syndrome
- Contraindications to radiotherapy as determined by physicians
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Westmead Hospital
Westmead, Australia
Actively Recruiting
Research Team
S
Saurabh Kumar, MBBS | PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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