Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05191940

Radiotherapy for Locally Advanced Pancreatic Carcinomas (Phase II Trial)

Led by EBG MedAustron GmbH · Updated on 2026-03-20

30

Participants Needed

1

Research Sites

341 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is an interventional, single-arm, open-label study with high dose short course radiotherapy for patients with locally advanced pancreatic cancer.

CONDITIONS

Official Title

Radiotherapy for Locally Advanced Pancreatic Carcinomas (Phase II Trial)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Histologically or cytologically confirmed pancreatic cancer, or radiological suspicion with elevated CA 19-9
  • Patient is not a candidate for radical surgical resection due to locally advanced unresectable disease or progression during neoadjuvant chemotherapy or cN+ stage
  • Patient is not a candidate for further neoadjuvant chemotherapy due to unfitness, progression, or unsuitability for surgery
  • No distant metastasis detected
  • Age over 18 years
  • Karnofsky performance status of 70 or higher
  • No tumor invasion into stomach or duodenum
  • Patient understands the diagnosis and can give informed consent
  • Women of childbearing potential use effective contraception and do not breastfeed
  • Signed informed consent available before inclusion
Not Eligible

You will not qualify if you...

  • Non-exocrine pancreatic tumors
  • Major medical or psychiatric conditions preventing radiotherapy
  • Presence of distant metastasis
  • Pregnancy or unwillingness to use contraception
  • Lactating and unwilling to stop breastfeeding
  • Men unwilling to use effective contraception
  • Metallic prosthesis or other conditions preventing adequate imaging for treatment planning
  • Previous abdominal radiotherapy
  • Severe liver or kidney impairment
  • Patient refusal to participate

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

EBG MedAustron GmbH

Wiener Neustadt, Lower Austria, Austria, 2700

Actively Recruiting

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Research Team

P

Piero Fossati, M.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

OTHER

Number of Arms

1

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