Non-Invasive Radiotracer Imaging to Assess Blood Flow in Leg Muscles of Adults With Peripheral Artery Disease Undergoing Revascularization

What this Trial Is About

This research aims to create a healthy database for nuclear perfusion imaging of the lower legs and to evaluate how well radiotracer-based imaging predicts clinical outcomes in patients with peripheral artery disease PAD undergoing lower leg revascularization. The study tests whether this imaging method can sensitively detect regional blood flow problems in leg muscles and monitor responses to treatment. Patients with PAD scheduled for revascularization will receive two types of imaging SPECTCT or PETCT perfusion scans. Each patient will get an intravenous injection of a radiotracer before and 1 to 14 days after their procedure. A low-dose CT scan will follow each imaging session for better image analysis. Additionally, a group of PAD patients and healthy volunteers will undergo the same imaging to help build a healthy reference database. Participants will complete medical and physical activity questionnaires, standard PAD screenings including Ankle-Brachial and Toe-Brachial Indices, and imaging sessions before and shortly after their revascularization. Researchers will monitor clinical outcomes such as wound healing and limb salvage for up to 12 months. The main measure is blood flow in the lower legs within 1 to 2 weeks after treatment, with ongoing safety and outcome tracking throughout the study period.

Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease