A Randomised Control Clinical Trial Investigating the Effect of Horizontal-Platelet-Rich Fibrin (H-PRF) vs Standard Placement on Implant Stability and Marginal Bone Levels in Adults

What this Trial Is About

Researchers are evaluating the effect of Horizontal Platelet Rich Fibrin (H-PRF) on the stability and bone levels of dental implants in adults. This randomized controlled clinical trial focuses on patients receiving dental implants in the upper or lower jaws at Dublin Dental University Hospital. H-PRF is a biologic material derived from patients' blood that may encourage bone growth and implant integration, and this study aims to compare implants placed with and without H-PRF to assess its potential benefits. Participants will be randomly assigned to one of two groups: one where implants are coated with H-PRF and another where implants are placed without H-PRF. The H-PRF is prepared by drawing blood from patients, then processing it in a horizontal centrifuge to create a clot used during implant placement. Implants will be placed using standard surgical protocols, and the procedure will be identical for both groups aside from the use of H-PRF. During the study, participants will have implant stability and bone levels measured at implant placement, three months later, and at the time of implant restoration (around 4 to 5 months). Pain levels will be recorded at various points after surgery, and the occurrence of implant loss, fracture, or infection will be monitored. Patients will also maintain symptom diaries and attend scheduled study visits. The study will last several months, with careful monitoring to evaluate the impact of H-PRF on dental implant success.

A Randomised Control Clinical Trial Investigating the Effect of H-PRF on Implant Stability and Marginal Bone Levels