Actively Recruiting
A Randomised Paired Design Study of Texture and Colour Enhancement Imaging (TXI) Versus High-definition White Light Endoscopy for Dysplasia Detection in IBD Surveillance
Led by London North West Healthcare NHS Trust · Updated on 2026-04-13
219
Participants Needed
1
Research Sites
16 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare two imaging techniques, Texture and Colour Enhancement Imaging (TXI) and high-definition white light endoscopy, for detecting dysplasia in patients with inflammatory bowel disease (IBD) undergoing surveillance colonoscopy. TXI improves texture, brightness, and colour in white-light endoscopy to highlight subtle tissue differences and has shown potential value in predicting ulcerative colitis relapse and detecting lesions. However, no randomized data exist to confirm its effectiveness for dysplasia detection in IBD surveillance, prompting this randomized paired design study. Participants in the study will be randomly assigned to undergo withdrawal using either TXI or high-definition white light endoscopy following standardized protocols. The study compares the proportion of patients with at least one dysplastic lesion detected by each method. Both imaging techniques are performed during surveillance colonoscopy to evaluate their ability to identify dysplasia in the colon. During the study, participants will undergo surveillance colonoscopy with one of the two imaging methods. Researchers will monitor and compare dysplasia detection rates within six months. The primary outcome measure is the proportion of patients with at least one dysplastic lesion detected by TXI versus white light endoscopy. Participants will be evaluated for safety and the study will continue until March 2029, with assessments conducted according to the study schedule.
CONDITIONS
Brief Title
A Randomised Paired Design Study of Texture and Colour Enhancement Imaging (TXI) Versus High-definition White Light Endoscopy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 16 years old with inflammatory bowel disease undergoing surveillance colonoscopy
- Patients with Crohn's disease involving more than 50% of the colon (L2/L3 Montreal classification)
- Patients with ulcerative colitis with extensive or left-sided disease (E3 or E2 Montreal classification) for at least 8 years
- Patients with primary sclerosing cholangitis along with IBD
- Ability to give informed consent and willingness to participate
You will not qualify if you...
- Disease duration less than 8 years unless diagnosed with primary sclerosing cholangitis
- Incomplete colonoscopy procedure
- Bowel preparation score (BBPS) less than 6 or less than 2 in any colon segment
- Mayo Endoscopic Score (MES) 2 or higher, or any SES-CD variable 2 or higher, or stenosis longer than 10 cm above the rectum
- Previous colorectal surgery
- Low platelet count below 50 or blood clotting problems preventing biopsy
- Use of blood thinners not properly stopped before the procedure
- Pregnancy
- Unable or unwilling to give informed consent or participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single procedure visit
Participants undergo surveillance colonoscopy using either Texture and Colour Enhancement Imaging (TXI) or high-definition white light endoscopy to detect dysplasia.
1 visit (in-person)
Duration - 6 months
Participants are monitored for up to 6 months following the colonoscopy to assess dysplasia detection outcomes.
Follow-up visits as per routine care
Trial Site Locations
Total: 1 location
1
Central Middlesex Hospital
London, United Kingdom, NW10 7NS
Actively Recruiting
Research Team
J
Jonathan Landy, Consultant Gastroenterologist
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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