Study Comparing Texture and Colour Enhancement Imaging TXI and High-definition White Light Endoscopy for Detecting Dysplasia in Inflammatory Bowel Disease Surveillance

What this Trial Is About

This research aims to compare two imaging techniques, Texture and Colour Enhancement Imaging TXI and high-definition white light endoscopy, for detecting dysplasia in patients with inflammatory bowel disease IBD undergoing surveillance colonoscopy. TXI improves texture, brightness, and colour in white-light endoscopy to highlight subtle tissue differences and has shown potential value in predicting ulcerative colitis relapse and detecting lesions. However, no randomized data exist to confirm its effectiveness for dysplasia detection in IBD surveillance, prompting this randomized paired design study. Participants in the study will be randomly assigned to undergo withdrawal using either TXI or high-definition white light endoscopy following standardized protocols. The study compares the proportion of patients with at least one dysplastic lesion detected by each method. Both imaging techniques are performed during surveillance colonoscopy to evaluate their ability to identify dysplasia in the colon. During the study, participants will undergo surveillance colonoscopy with one of the two imaging methods. Researchers will monitor and compare dysplasia detection rates within six months. The primary outcome measure is the proportion of patients with at least one dysplastic lesion detected by TXI versus white light endoscopy. Participants will be evaluated for safety and the study will continue until March 2029, with assessments conducted according to the study schedule.

A Randomised Paired Design Study of Texture and Colour Enhancement Imaging (TXI) Versus High-definition White Light Endoscopy