Actively Recruiting
A Randomised Trial of Cabazitaxel, Docetaxel, Mitoxantrone or Satraplatin (CDMS) Plus Surgery for Prostate Cancer Patients
Led by Shanghai Jiao Tong University School of Medicine · Updated on 2026-01-12
300
Participants Needed
2
Research Sites
673 weeks
Total Duration
On this page
Sponsors
S
Shanghai Jiao Tong University School of Medicine
Lead Sponsor
F
Fudan University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Current agents administered in therapeutic regimens of prostate cancer employ different mechanisms to eliminate neoplastic cells by inducing substantial apoptosis and causing tumor regression. Treatment with neoadjuvant chemotherapy before radical prostatectomy may better control the tumor before it has the chance to convert into the disease of castration-resistant prostate cancer (CRPC), which is finally refractory to most modalities of clinical intervention with a clinically lethal nature.
CONDITIONS
Official Title
A Randomised Trial of Cabazitaxel, Docetaxel, Mitoxantrone or Satraplatin (CDMS) Plus Surgery for Prostate Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 75 years with confirmed prostate cancer by tissue examination
- No severe major organ dysfunction
- WHO performance status of 0 or 1
- No prior cancer chemotherapy
- Clinical stage at least T2c (T2c, N0, M0) prostate cancer without distant metastasis as shown by preoperative evaluation including CT scan
You will not qualify if you...
- Age 76 years or older
- Severe major organ dysfunction
- WHO performance status greater than 1
- Prior cancer chemotherapy
- Stage IV prostate cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Qilu Hospital of Shandong University
Qingdao, Shandong, China, 266035
Actively Recruiting
2
Zhongshan Hospital
Shanghai, China, 200032
Actively Recruiting
Research Team
Y
Yu Sun, Ph.D
CONTACT
W
Weijun Ma, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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