Actively Recruiting
A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence
Led by UConn Health · Updated on 2026-04-21
187
Participants Needed
1
Research Sites
96 weeks
Total Duration
On this page
Sponsors
U
UConn Health
Lead Sponsor
T
The Center for Advanced Reproductive Services, P.C.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.
CONDITIONS
Official Title
A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants aged 18 to 42 years
- Nonpregnant females
- Participants providing at least 6 mature oocytes for ICSI or at least 8 oocytes for standard insemination at egg retrieval
- Using standard insemination or ICSI for fertilization
- Undergoing genetic testing for aneuploidy or monogenic disorders (PGT-A or PGT-M)
- Willing to comply with study procedures and provide written informed consent
You will not qualify if you...
- Use of donor eggs, donor sperm, or gestational carriers
- Diagnosis of cryptozoospermia (no sperm found in fresh semen sample)
- Use of surgically retrieved sperm (e.g., testicular or epididymal aspiration)
- Use of frozen or thawed sperm samples
- Use of frozen or thawed oocytes
- Undergoing genetic testing for structural rearrangements (PGT-SR)
- Having a day 3 embryo transfer (cleavage stage)
- Producing fewer than 6 mature oocytes for ICSI or fewer than 8 for standard insemination at egg retrieval
- Fertilizing fewer than required mature oocytes (less than 6 for ICSI or less than 8 for standard insemination)
- Male partner unable to produce a second semen sample within three hours of the first
- Male partner has an infectious disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Center for Advanced Reproductive Services, P.C.
Farmington, Connecticut, United States, 06032
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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