A Double-Blinded Prospective Randomized Clinical Trial Comparing Euploidy Rates Among Embryos Created From Sibling Oocytes Exposed to Sperm After Ultrashort Abstinence Compared With Standard Abstinence

What this Trial Is About

Researchers are investigating whether producing sperm after a very short abstinence period of just 1 hour can improve the rates of embryos with normal chromosomes during in vitro fertilization (IVF) treatment. The study aims to compare this ultrashort abstinence with the current standard abstinence period of 2 to 5 days to see if it leads to better embryo quality and pregnancy outcomes. This research is focused on couples experiencing infertility, particularly male factor infertility, and is sponsored by UConn Health. Participants will provide two sperm samples on the day of egg retrieval: one after the standard 2-5 days of abstinence and another after only 1 hour of abstinence. Their eggs will be randomly divided into two groups, with half fertilized using sperm from the standard abstinence sample and the other half fertilized using sperm from the ultrashort abstinence sample. Both groups will be part of the IVF process involving insemination or injection of sperm into the eggs. The study will assess embryo chromosome normality and other IVF outcomes. During the study, participants will undergo egg retrieval and fertilization procedures, with close monitoring of embryo development. Researchers will evaluate the rate of chromosomally normal embryos within 2 to 4 weeks of the IVF cycle, as well as pregnancy rates after embryo transfer, fertilization rates, and blastulation rates. Participation lasts through these IVF cycle stages, with data collected to understand how sperm abstinence timing affects embryo quality and pregnancy chances.

A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence