Actively Recruiting
Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the M2 Segment of Middle Cerebral Artery
Led by Hyogo Medical University · Updated on 2026-02-24
200
Participants Needed
2
Research Sites
225 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
RESCUE-M2O trial is a prospective, open label, blinded endpoint (PROBE), two-arm, randomized, controlled, post-market study to assess the efficacy and safety of endovascular therapy for acute ischemic stroke with occlusion of the M2 segment of the middle cerebral artery.
CONDITIONS
Official Title
Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the M2 Segment of Middle Cerebral Artery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute cerebral infarction
- Aged 18 to 84 years
- NIH Stroke Scale score at admission 8 or higher
- Prestroke modified Rankin Scale scores of 0-1 (able to carry out all usual activities)
- Occlusion of the M2 segment of middle cerebral artery confirmed by digital subtraction angiography
- ASPECTS or DWI-ASPECTS score 8 or higher
- Ineligible for or failed intravenous tPA (no recanalization within 30 minutes after injection)
- Randomization completed within 24 hours from last known well time
- Endovascular therapy can be started within 30 minutes from randomization
- Signed informed consent by patient or legally authorized representative
You will not qualify if you...
- Occlusion of anterior temporal artery, duplicate M1, or accessory M1
- Occlusion of multiple major intracranial arteries
- Difficulty in endovascular access due to tortuous vascular anatomy
- Significant brain swelling with midline shift on CT or MRI
- Known allergy more severe than skin rash to contrast agents
- Evidence of acute intracranial hemorrhage on CT or MRI
- Pregnant or potentially pregnant
- Clinical evidence of chronic occlusion
- High risk of hemorrhage (platelets less than 40,000/µl, APTT greater than 50 seconds, or PT-INR greater than 3.0)
- Participation in another therapeutic investigational trial
- Investigator judgment of non-compliance or uncooperativeness during the study
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Hyogo Medical University
Nishinomiya, Hyōgo, Japan, 663-8501
Not Yet Recruiting
2
Hyogo Medical University
Nishinomiya, Hyōgo, Japan, 663-8501
Actively Recruiting
Research Team
K
Kazutaka Uchida, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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