Actively Recruiting
A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block
Led by McGill University Health Centre/Research Institute of the McGill University Health Centre · Updated on 2026-01-07
69
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will compare three different doses of perineural dexmedetomidine 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg as adjuvants to local anesthetics for ultrasound-guided infraclavicular brachial plexus blocks (ICBs). Our research hypothesis is that 1.33 mcg/kg will provide a 15%-longer duration than 1mcg/kg, which in turn will provide a 15%-longer duration than 0.67 mcg/kg. Since analgesic duration and sensory duration can be influenced by intake of pain medications and surgical trauma to small cutaneous nerves, respectively, we will select motor block duration as the main outcome to better target the action of dexmedetomidine on the brachial plexus.
CONDITIONS
Official Title
A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing upper limb surgery at or below the elbow
- Age between 18 and 75 years
- American Society of Anesthesiologists classification 1-3
- Body mass index between 18 and 35 kg/m2
You will not qualify if you...
- Adults unable to give their own consent
- Allergy or contraindication to dexmedetomidine
- Exposure to dexmedetomidine in the previous 48 hours
- Pre-existing neuropathy
- Coagulopathy or blood clotting disorders
- Renal failure
- Hepatic failure
- Allergy to local anesthetics
- Pregnancy
- Breastfeeding
- Prior surgery in the infraclavicular region
- Chronic pain requiring opioid use at home
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
McGill University Health Centre
Montreal, Quebec, Canada, H3G 1A4
Actively Recruiting
Research Team
J
Julián Aliste, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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