A Randomized Comparison Between 0.67 mcgkg, 1 mcgkg, and 1.33 mcgkg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block

Led by McGill University Health Centre/Research Institute of the McGill University Health Centre · Updated on 2026-07-07

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This study will compare three different doses of perineural dexmedetomidine 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg as adjuvants to local anesthetics for ultrasound-guided infraclavicular brachial plexus blocks (ICBs). Our research hypothesis is that 1.33 mcg/kg will provide a 15%-longer duration than 1mcg/kg, which in turn will provide a 15%-longer duration than 0.67 mcg/kg. Since analgesic duration and sensory duration can be influenced by intake of pain medications and surgical trauma to small cutaneous nerves, respectively, we will select motor block duration as the main outcome to better target the action of dexmedetomidine on the brachial plexus.

CONDITIONS

Brief Title

A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block

Who Can Participate

Age: 18Years - 75Years

All Genders

Eligibility Criteria

Inclusion Criteria:

patients undergoing upper limb surgery at or below the elbow
age between 18 and 75 years
American Society of Anesthesiologists classification 1-3
body mass index between 18 and 35 kg/m2

Exclusion Criteria:

adults who are unable to give their own consent
allergy or contraindication to dexmedetomidine
exposure to dexmedetomidine during the previous 48 hrs
pre-existing neuropathy (assessed by history and physical examination)
coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood workup i.e. platelets ≤ 100, International Normalized Ratio ≥ 1.4 or partial prothrombin time ≥ 50)
renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. creatinine. eGFR < 90)
hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. transaminases ≥ 100)
allergy to LA
pregnancy (as institutional policy, female patients with childbearing potential undergoing non urgent surgery are tested preoperatively for pregnancy with blood tests)
breast feeding
prior surgery in the infraclavicular region
chronic pain syndromes requiring opioid intake at home

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