Actively Recruiting
Randomized Comparison of Partial Wrist Fusion With or Without Triquetral Excision to Treat Post-Traumatic Wrist Arthritis
Led by University of Alberta · Updated on 2025-11-18
170
Participants Needed
6
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Alberta
Lead Sponsor
A
Arthritis Society Canada
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating different partial wrist fusion surgeries for adults with post-traumatic wrist arthritis, specifically those with stage II or III scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC). This randomized clinical trial aims to compare clinical and radiographic outcomes of two wrist fusion techniques to help guide surgeons on the best surgical option for managing this condition. Participants will be randomly assigned to one of two groups. Group A will have four-corner arthrodesis, where the scaphoid is removed and the lunate, capitate, triquetrum, and hamate bones are fused. Group B will have partial wrist arthrodesis with triquetral excision, which removes both the scaphoid and triquetrum and fuses either three or two of the wrist bones depending on the procedure. These surgeries are studied in a multi-center double-blind design. Participants will have assessments before surgery and at 6 weeks, 3, 6, and 12 months after surgery. Evaluations include grip strength measurement, wrist range of motion, pain scales, and various questionnaires on wrist function and work-related abilities. Standard wrist X-rays and complication tracking will also be done. The main outcome is grip strength compared between groups over 12 months, with statistical analysis adjusting for age and sex.
CONDITIONS
Brief Title
Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant has stage II or III scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC) wrist arthritis
- Participant is an adult aged 18 to 75 years
- Participant is a surgical candidate for the included wrist fusion procedures
- Participant is able to understand English and complete study questionnaires
You will not qualify if you...
- Participant has other forms of wrist arthritis besides SLAC or SNAC
- Participant has significant arthritis in the same hand or finger joints, major joint trauma, previous major wrist surgery, infection, or neuromuscular problems affecting wrist function
- Participant has physical or mental health conditions preventing consent or questionnaire completion
- Participant does not speak, read, or understand English
- Participant has no fixed address or reliable contact method
- Participant is unwilling to complete required follow-ups
- Surgeon determines the wrist fusion techniques are inappropriate at surgery due to injury or wrist issues
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day of surgery
Participants undergo one of two partial wrist arthrodesis procedures to treat wrist arthritis.
1 surgical visit (in-person)
Duration - 12 months post-surgery
Participants attend follow-up assessments to measure grip strength, wrist range of motion, pain, and complete patient questionnaires while monitoring complications.
Follow-up visits at 6-weeks, 3 months, 6 months, and 12 months post-surgery (in-person)
Trial Site Locations
Total: 6 locations
1
Peter Lougheed Centre
Calgary, Alberta, Canada
Actively Recruiting
2
South Health Campus
Calgary, Alberta, Canada
Actively Recruiting
3
Western Hand & Upper Limb Facility, Sturgeon Community Hospital
St. Albert, Alberta, Canada
Actively Recruiting
4
Lawson Health Research Institute
London, Ontario, Canada
Actively Recruiting
5
The Ottawa Hospital - Civic Campus
Ottawa, Ontario, Canada
Actively Recruiting
6
University of Saskatchewan
Saskatoon, Saskatchewan, Canada
Actively Recruiting
Research Team
D
Dr. Armin Badre, MD, MSc, FRCSC
C
Collaborative Orthopaedic Research (CORe)
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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