Actively Recruiting
A Randomized Comparison of Personalized Therapy Mgmt Based On Coronary Atherosclerotic Plaque Vs. Usual Care for Symptomatic Patients With Suspicion of CAD
Led by Cleerly, Inc. · Updated on 2026-03-18
1000
Participants Needed
21
Research Sites
93 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
PARAMOUNT is a prospective randomized open-label trial testing the hypothesis that a personalized management strategy in symptomatic patients with suspicion of coronary artery disease (CAD), using a CT-based coronary atherosclerotic plaque assessment by AI-enabled quantitative software improves: certainty for diagnosis of CAD, control of CAD risk factors and efficiency of ICA referral with appropriate PCI compared to the usual care strategy based on current AHA/ACC guidelines for care of symptomatic patients with suspicion of CAD.
CONDITIONS
Official Title
A Randomized Comparison of Personalized Therapy Mgmt Based On Coronary Atherosclerotic Plaque Vs. Usual Care for Symptomatic Patients With Suspicion of CAD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Older than 18 years
- Symptomatic patients suspected of having coronary artery disease, including those referred for elective, non-urgent diagnostic testing such as stress tests
You will not qualify if you...
- LDL cholesterol level less than 100 mg/dL
- Currently or previously treated beyond primary prevention guidelines
- Suspected acute coronary syndrome or unstable clinical status
- Planned cardiovascular procedures like coronary angiography, cardiac surgery, or non-coronary vascular procedures
- Noninvasive or invasive cardiovascular testing for coronary artery disease within the past year
- Known history of obstructive coronary artery disease (prior myocardial infarction, coronary artery bypass grafting, percutaneous coronary intervention, or stenosis 50% or greater)
- Known ejection fraction 40% or less or other moderate to severe valvular or congenital heart disease
- Contraindications to coronary CT angiography
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 21 locations
1
Cardiology Associates of Mobile
Mobile, Alabama, United States, 36608
Actively Recruiting
2
Valiance Clinical Research- Huntington Park
Huntington Park, California, United States, 90255
Actively Recruiting
3
Cardiovascular Institute of San Diego
San Diego, California, United States, 91911
Actively Recruiting
4
Valiance Clinical Research- Tarzana
Tarzana, California, United States, 91356
Actively Recruiting
5
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, United States, 90502
Actively Recruiting
6
Intermountain Health Saint Joseph Hospital
Broomfield, Colorado, United States, 80021
Actively Recruiting
7
Tampa Cardiovascular Interventions and Research
Tampa, Florida, United States, 33614
Actively Recruiting
8
Flourish Research
Winter Park, Florida, United States, 32789
Actively Recruiting
9
Endeavor Health Clinical Operations
Evanston, Illinois, United States, 60201
Actively Recruiting
10
MercyOne Des Moines Medical Center
West Des Moines, Iowa, United States, 50266
Actively Recruiting
11
Saint Elizabeth Medical Center
Edgewood, Kentucky, United States, 41017
Actively Recruiting
12
Tulane University
New Orleans, Louisiana, United States, 70112
Actively Recruiting
13
Flourish- Bowie
Bowie, Maryland, United States, 20715
Actively Recruiting
14
St. Louis Heart and Vascular
Bridgeton, Missouri, United States, 63044
Actively Recruiting
15
Advanced Heart and Vascular Institute of Hunterdon
Flemington, New Jersey, United States, 08822
Actively Recruiting
16
Capital Cardiology Associates
Albany, New York, United States, 12211
Actively Recruiting
17
University of Cincinnatti
Cincinnati, Ohio, United States, 45221
Actively Recruiting
18
Oklahoma Cardiovascular Research Group
Oklahoma City, Oklahoma, United States, 73120
Actively Recruiting
19
The University of Tennessee Medical Center
Knoxville, Tennessee, United States, 37920
Actively Recruiting
20
Medical City Fort Worth Hospital
Fort Worth, Texas, United States, 76104
Actively Recruiting
21
Chippenham and Johnston Willis Hospitals
Richmond, Virginia, United States, 23225
Actively Recruiting
Research Team
R
Ryann Sardinia
CONTACT
V
Vidhya Kumar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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