Clinical Trial of 44C Local Hyperthermia Combined with 3% Hydrogen Peroxide for Treating Viral Warts

What this Trial Is About

Researchers are evaluating the use of mild local hyperthermia combined with 3% hydrogen peroxide to treat viral warts, including common warts, plantar warts, and condyloma acuminatum. The study aims to assess the safety and effectiveness of warming the skin to 44C alongside applying hydrogen peroxide to clear wart lesions. This treatment approach is being compared to using either hyperthermia or hydrogen peroxide alone in a randomized clinical trial. Participants receive one of three treatments local hyperthermia alone applied to the largest wart, topical 3% hydrogen peroxide solution alone with simulated infrared light, or a combination where 3% hydrogen peroxide dressing is applied one hour before a 30-minute session of local hyperthermia at 44C. Hyperthermia treatments occur daily for three days, then twice weekly for three weeks, totaling seven sessions. Hydrogen peroxide is applied with cotton balls soaked in the solution as a dressing, and saline dressings are used during hyperthermia treatments. During the study, participants are monitored for wart clearance up to six months after treatment begins. Researchers measure complete clearance rates, time to clearance, and recurrence of warts. Secondary assessments include changes in wart size and number, pain during treatment sessions, adverse events, and patient satisfaction. Treatment sessions, follow-up visits, and safety monitoring are conducted over several weeks, with data collected at multiple intervals throughout the six-month period.

Randomized Controlled Clinical Trial of Hyperthermia and Hydrogen Peroxide 3% in the Treatment of Cutaneous Warts